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Year : 2012  |  Volume : 1  |  Issue : 1  |  Page : 34-36

Response to thrombolytic agents in acute myocardial infarction in opium abusers versus non-abusers

Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Mohaddeseh Behjati
Department of Cardiology, Isfahan University of Medical Sciences, Isfahan
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Source of Support: None, Conflict of Interest: None

PMID: 24991586

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Objective: Coronary artery disease is one of the leading causes of morbidity and mortality in populations. In opium abusers, level of circulating coagulation factors differs from non-abusers. The aim of this study was to evaluate response to thrombolytic therapy in opium abusers vs. non-abusers. Methods: In this prospective observational study, 83 patients (36 opium abusers and 47 non-abusers) with AMI were evaluated for the presence and degree of response to thrombolytic agent. All patients were monitored for electrocardiographic changes and response to thrombolysis 2 hours before and after administration of thrombolytic agent. Serum CPK and LDH were measured 2 hours before and after thrombolysis. Quantitative and qualitative data were analyzed by independent t-test and chi-square using SPSS, respectively. Findings: ST-resolution 2 hours after thrombolysis was 63.8% and 44.4% in opium users and non-users, respectively. Serum level of CPK cardiac biomarker 2 hours after thrombolysis was 980 ± 245 and 847 ± 130 IU/L in opium users and non-users, respectively. Conclusion: Our data demonstrate that in those patients with opium abuse, electrocardiographic changes after thrombolysis were significantly lower than opium non-users (P < 0.05). Opium users showed better ST-resolution compared with non-users. Opium addiction had effect on cardiac enzymes despite their effect on response to streptokinase.

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