Home Print this page Email this page Small font size Default font size Increase font size
Users Online: 480
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Contacts Login 
BRIEF COMMUNICATION
Year : 2012  |  Volume : 1  |  Issue : 1  |  Page : 34-36

Response to thrombolytic agents in acute myocardial infarction in opium abusers versus non-abusers


Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Mohaddeseh Behjati
Department of Cardiology, Isfahan University of Medical Sciences, Isfahan
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 24991586

Rights and PermissionsRights and Permissions

Objective: Coronary artery disease is one of the leading causes of morbidity and mortality in populations. In opium abusers, level of circulating coagulation factors differs from non-abusers. The aim of this study was to evaluate response to thrombolytic therapy in opium abusers vs. non-abusers. Methods: In this prospective observational study, 83 patients (36 opium abusers and 47 non-abusers) with AMI were evaluated for the presence and degree of response to thrombolytic agent. All patients were monitored for electrocardiographic changes and response to thrombolysis 2 hours before and after administration of thrombolytic agent. Serum CPK and LDH were measured 2 hours before and after thrombolysis. Quantitative and qualitative data were analyzed by independent t-test and chi-square using SPSS, respectively. Findings: ST-resolution 2 hours after thrombolysis was 63.8% and 44.4% in opium users and non-users, respectively. Serum level of CPK cardiac biomarker 2 hours after thrombolysis was 980 ± 245 and 847 ± 130 IU/L in opium users and non-users, respectively. Conclusion: Our data demonstrate that in those patients with opium abuse, electrocardiographic changes after thrombolysis were significantly lower than opium non-users (P < 0.05). Opium users showed better ST-resolution compared with non-users. Opium addiction had effect on cardiac enzymes despite their effect on response to streptokinase.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2569    
    Printed170    
    Emailed0    
    PDF Downloaded386    
    Comments [Add]    

Recommend this journal