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BRIEF COMMUNICATION
Year : 2019  |  Volume : 8  |  Issue : 3  |  Page : 168-173

Drug therapeutic failures as a cause of admission to an intensive care unit at a university hospital


1 Department of Biomedical Sciences, Pharmacology Unit, Universidad del Rosario, Bogotá, Colombia
2 Department of Biomedical Sciences, Pharmacology Unit; Center for Research in Genetics and Genomics, GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia

Correspondence Address:
Prof. Carlos-Alberto Calderon-Ospina
Department of Biomedical Sciences, Pharmacology Unit; Center for Research in Genetics and Genomics, GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá , Colombia
Colombia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrpp.JRPP_18_69

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Objective: Drug therapeutic failures (TFs) are included in pharmacovigilance reporting, as some authors consider them a type of adverse drug reaction. Given their high frequency in Colombia, we studied their importance as a cause of admission to an intensive care unit (ICU). Methods: This was a cross-sectional observational study. Clinical records of patients who arrived at the emergency service of a third-care level university hospital were reviewed. Information was collected by a resident in clinical toxicology, and each case was validated and analyzed by a research team using the algorithm proposed by Vaca González and Schumock and Thornton criteria for preventability to evaluate the existence of possible medication errors. Findings: In total, 697 clinical records were evaluated and 18 patients presented TFs (2.6%, 95% confidence interval 1.5%–4.1%) as the cause of admission to the ICU. The most frequent TFs were seizures (56%) and hypertension (28%). The most commonly associated medications were valproic acid (28%) and losartan (28%). Ten cases (56%) were associated with drug misuse and the same number of cases was preventable, according to Schumock and Thornton criteria. Conclusion: This is the first study assessing TFs as a cause of admission to the ICU in the Colombian population. The frequency of TFs in our study was similar to that described in the literature; being the most common cause the inappropriate drug use, particularly for drugs with complex kinetics, such as antiepileptic drugs.


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