Journal of Research in Pharmacy Practice

BRIEF COMMUNICATION
Year
: 2012  |  Volume : 1  |  Issue : 1  |  Page : 34--36

Response to thrombolytic agents in acute myocardial infarction in opium abusers versus non-abusers


Seyed Mohammad Hashemi Jazi, Idin Ahang Nazary, Mohaddeseh Behjati 
 Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Mohaddeseh Behjati
Department of Cardiology, Isfahan University of Medical Sciences, Isfahan
Iran

Objective: Coronary artery disease is one of the leading causes of morbidity and mortality in populations. In opium abusers, level of circulating coagulation factors differs from non-abusers. The aim of this study was to evaluate response to thrombolytic therapy in opium abusers vs. non-abusers. Methods: In this prospective observational study, 83 patients (36 opium abusers and 47 non-abusers) with AMI were evaluated for the presence and degree of response to thrombolytic agent. All patients were monitored for electrocardiographic changes and response to thrombolysis 2 hours before and after administration of thrombolytic agent. Serum CPK and LDH were measured 2 hours before and after thrombolysis. Quantitative and qualitative data were analyzed by independent t-test and chi-square using SPSS, respectively. Findings: ST-resolution 2 hours after thrombolysis was 63.8% and 44.4% in opium users and non-users, respectively. Serum level of CPK cardiac biomarker 2 hours after thrombolysis was 980 ± 245 and 847 ± 130 IU/L in opium users and non-users, respectively. Conclusion: Our data demonstrate that in those patients with opium abuse, electrocardiographic changes after thrombolysis were significantly lower than opium non-users (P < 0.05). Opium users showed better ST-resolution compared with non-users. Opium addiction had effect on cardiac enzymes despite their effect on response to streptokinase.


How to cite this article:
Jazi SH, Nazary IA, Behjati M. Response to thrombolytic agents in acute myocardial infarction in opium abusers versus non-abusers.J Res Pharm Pract 2012;1:34-36


How to cite this URL:
Jazi SH, Nazary IA, Behjati M. Response to thrombolytic agents in acute myocardial infarction in opium abusers versus non-abusers. J Res Pharm Pract [serial online] 2012 [cited 2020 Jun 7 ];1:34-36
Available from: http://www.jrpp.net/article.asp?issn=2319-9644;year=2012;volume=1;issue=1;spage=34;epage=36;aulast=Jazi;type=0