Journal of Research in Pharmacy Practice

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 2  |  Issue : 1  |  Page : 24--28

Hypercapnic hyperventilation shortens emergence time from Propofol and Isoflurane anesthesia


Ahmad Yaraghi, Mohammad Golparvar, Reihanak Talakoub, Hossein Sateie, Ali Mehrabi 
 Department of Anesthesia and Critical Care, Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Mohammad Golparvar
Department of Anesthesia and Critical Care, Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan
Iran

Objective: The aim of this study is to compare the effects of hypercapnic hyperventilation and normocapnic normoventilation on emergence time from propofol and isoflurane anesthesia. Methods: In this clinical trial, the differences in emergence time were evaluated in 80 patients undergoing elective abdominal surgery in Alzahra University hospital, Isfahan, Iran, in 2011-2012. Patients were randomly divided into four groups (groups 1-4) receiving isoflurane hypercapnic hyperventilation, isoflurane normocapnic normoventilation, propofol hypercapnic hyperventilation, and propofol normocapnic normoventilation, respectively. Hypercapnia was maintained by adding CO 2 to the patient«SQ»s inspired gas during hyperventilation. The emergence time and the duration of stay in recovery room in the four groups were measured and compared by one-way analysis of variance (ANOVA) and least significant difference tests. Findings: The average emergence time in groups 1, 2, 3, and 4 were (11.3 ± 3.2), (15.2 ± 3.8), (9 ± 4.2) and (11.8 ± 5.3) min, respectively. These differences were significant ( P = 0.001). In patients receiving propofol hypercapnic hyperventilation, the emergence time was faster than in other groups. There was also a significant difference in duration of stay in recovery room between the groups ( P = 0.004). Patients who received isoflurane hypercapnic hyperventilation had a shortest length of stay in the recovery room. Conclusion: The emergence time after intravenous anesthesia with propofol can be shortened significantly by using hyperventilation and hypercapnia, without any side effects.


How to cite this article:
Yaraghi A, Golparvar M, Talakoub R, Sateie H, Mehrabi A. Hypercapnic hyperventilation shortens emergence time from Propofol and Isoflurane anesthesia.J Res Pharm Pract 2013;2:24-28


How to cite this URL:
Yaraghi A, Golparvar M, Talakoub R, Sateie H, Mehrabi A. Hypercapnic hyperventilation shortens emergence time from Propofol and Isoflurane anesthesia. J Res Pharm Pract [serial online] 2013 [cited 2020 Jun 7 ];2:24-28
Available from: http://www.jrpp.net/article.asp?issn=2319-9644;year=2013;volume=2;issue=1;spage=24;epage=28;aulast=Yaraghi;type=0