Journal of Research in Pharmacy Practice

REVIEW ARTICLE
Year
: 2018  |  Volume : 7  |  Issue : 4  |  Page : 171--177

The clinical efficacy of imiglucerase versus eliglustat in patients with Gaucher's disease Type 1: A systematic review


Azita Nabizadeh1, Bahman Amani2, Maliheh Kadivar3, Mahdi Toroski1, Akbar Abdollahi Asl1, Yahya Bayazidi1, Mahdi Mojahedian1, Majid Davari4 
1 Department of Pharmacoeconomics and Pharmaceutical Administration, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Health Science Education Development, Tehran University of Medical Sciences, Tehran, Iran
3 Division of Neonatology, Department of Pediatrics, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Pharmacoeconomics and Pharmaceutical Administration; Pharmaceutical Management and Economics Research Center, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Dr. Majid Davari
Department of Pharmacoeconomics and Pharmaceutical Administration; Pharmaceutical Management and Economics Research Center, Tehran University of Medical Sciences, Tehran
Iran

Gaucher's disease (GD) is one of the most common lysosomal diseases in humans. It results from β-glucosidase deficiency and leads to necrosis, especially in macrophages with the accumulation of glucosylceramidase in cells. Most of the deleterious effects of the disease are seen in the liver, spleen, and bone marrow. The aim of this study was to compare the efficacy of Imiglucerase with Eliglustat in treating patients with GD. PubMed/Medline, Cochrane Library, Scopus, Web of Science, Embase, and Google Scholar were searched from inception to August, 2018. Predefined inclusion criteria for included studies were based on search methodology and are as follows: All randomized, quasi-randomized controlled, and cohort studies about patients with GD Type 1 that Imiglucerase was compared with Eliglustat were included. Two authors independently choose the papers based on the inclusion criteria. From 2979 recognized studies, three studies including two randomized clinical trials and one cohort study were recognized to meet the inclusion criteria. The primary outcomes were hemoglobin level, platelets count, liver, and spleen size, and the secondary outcomes were the immunological side effects of the medicines and bone complications. The results showed that there is no meaningful difference between the two medicines in terms of increasing blood hemoglobin, platelets count, and reducing the liver and spleen size. The findings of this review showed that both medicines are effective in the treatment of GD Type 1 and there is no statistically significant difference between their efficacies.


How to cite this article:
Nabizadeh A, Amani B, Kadivar M, Toroski M, Asl AA, Bayazidi Y, Mojahedian M, Davari M. The clinical efficacy of imiglucerase versus eliglustat in patients with Gaucher's disease Type 1: A systematic review.J Res Pharm Pract 2018;7:171-177


How to cite this URL:
Nabizadeh A, Amani B, Kadivar M, Toroski M, Asl AA, Bayazidi Y, Mojahedian M, Davari M. The clinical efficacy of imiglucerase versus eliglustat in patients with Gaucher's disease Type 1: A systematic review. J Res Pharm Pract [serial online] 2018 [cited 2019 Jun 26 ];7:171-177
Available from: http://www.jrpp.net/article.asp?issn=2319-9644;year=2018;volume=7;issue=4;spage=171;epage=177;aulast=Nabizadeh;type=0