Journal of Research in Pharmacy Practice

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 7  |  Issue : 4  |  Page : 182--187

Impact of protocol implementation on rationalization of albumin use in a tertiary care teaching hospital in Tehran, Iran


Sholeh Ebrahimpour1, Marzieh Nosrati2, Mehdi Mohammadi3, Haniyeh Kamyab4, Amir Sarayani5, Habibollah Mahmoodzadeh6, Zahra Jahangard-Rafsanjani1, Kheirollah Gholami1 
1 Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Pharmacoeconomics and Pharmaceutical Management, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Clinical Pharmacy, Alborz University of Medical Sciences, Karaj, Iran
4 Department of Pharmaceutical Biotechnology, Tehran University of Medical Sciences, Tehran, Iran
5 Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran
6 Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Dr. Zahra Jahangard-Rafsanjani
Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran
Iran

Objective: With respect to the high cost and limited availability of albumin, its use must be restricted to indications strongly supported by solid scientific evidence. It was anticipated that with the implementation of the National Health Reform Plan (NHRP), the consumption of albumin would increase as the result of decreasing patients' out-of-pocket costs. This study aimed to evaluate the efficacy of protocol implementation on the rationalization of albumin use in surgery wards of Cancer Institute of Imam Khomeini Hospital Complex, Tehran, Iran. Methods: This pre-post interventional study was conducted in 32-month phases from January to November 2014 in an Iranian University hospital. The first phase was before the implementation of NHRP, the second phase was after NHRP, and the last one was after the intervention. The first and second phases were conducted retrospectively. Data extraction was performed by a hospital pharmacist. During the third phase, the physicians were mandated to adhere to a local albumin protocol which had been prepared by clinical pharmacy service and approved by drug and therapeutic committee. Appropriateness of prescriptions regarding indication, dose, and duration based on local guideline was compared among groups. Findings: Although hospital bed-days of care remained consistent among phases, albumin was prescribed for 40, 45, and 8 patients during first, second, and third phases, respectively. This shows about 80% reduction of drug prescriptions in the last phase. The mean duration/dose of albumin in inappropriate indications reduced significantly from 11.3 ± 8.2 days/24.7 ± 21.2 vials in the second phase to 2.6 ± 1.7 days/5.6 ± 3.5 vials in the third phase, respectively (P = 0.001 and P = 0.003). Conclusion: Interactive collaboration through guideline implementation seems effective in rationalizing the use of high-cost medications such as albumin.


How to cite this article:
Ebrahimpour S, Nosrati M, Mohammadi M, Kamyab H, Sarayani A, Mahmoodzadeh H, Jahangard-Rafsanjani Z, Gholami K. Impact of protocol implementation on rationalization of albumin use in a tertiary care teaching hospital in Tehran, Iran.J Res Pharm Pract 2018;7:182-187


How to cite this URL:
Ebrahimpour S, Nosrati M, Mohammadi M, Kamyab H, Sarayani A, Mahmoodzadeh H, Jahangard-Rafsanjani Z, Gholami K. Impact of protocol implementation on rationalization of albumin use in a tertiary care teaching hospital in Tehran, Iran. J Res Pharm Pract [serial online] 2018 [cited 2019 Mar 19 ];7:182-187
Available from: http://www.jrpp.net/article.asp?issn=2319-9644;year=2018;volume=7;issue=4;spage=182;epage=187;aulast=Ebrahimpour;type=0