Journal of Research in Pharmacy Practice

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 8  |  Issue : 1  |  Page : 7--12

Early effects of atorvastatin on Vitamin D and parathyroid hormone serum levels following acute myocardial infarction


Batool Zarei1, Maryam Mousavi2, Saeideh Mehdizadeh3, Hassan Mehrad-Majd4, Maryam Zarif5, Zahra Erfanian5, Ali Moradi6 
1 Department of Clinical Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
2 Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Clinical Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
4 Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran
5 Department of Cardiology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
6 Clinical Research Unit; Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence Address:
Dr. Ali Moradi
Clinical Research Unit; Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad
Iran

Objective: High Vitamin D serum level after acute myocardial infarction (aMI) has shown to increase cardiac reconstruction by increasing cell survival and enhancing angiogenesis. Atorvastatin has a well-defined role in both primary and secondary prevention of cardiovascular diseases. It is suggested that this effect may partly be attributable to raising 25-hydroxyvitamin D concentrations. The aim of this study was to evaluate atorvastatin effects on Vitamin D and parathyroid hormone (PTH) levels early after aMI. Methods: All patients admitted with aMI in Imam Reza Hospital, Mashhad, Iran, from July 2014 to March 2015, were included in this pre- and postintervention study. Serum levels of Vitamin D and PTH were measured on admission and the 3rd day after administration of atorvastatin 80 mg/day. Findings: A total of 69 post-aMI patients (47 males and 22 females) were enrolled in this study. Serum levels of Vitamin D and PTH were significantly higher (23.52 ng/ml and 46.04 pg/ml, respectively) after 72 h of atorvastatin therapy compared to the baseline (19.66 ng/ml and 31.19 pg/ml, respectively) (P = 0.004 and 0.002, respectively). Conclusion: The early post-aMI beneficial effects of atorvastatin can be attributed to increased serum Vitamin D level; however, atorvastatin cannot significantly decrease serum PTH level after aMI. Further studies are needed to elucidate the clinical effect of atorvastatin.


How to cite this article:
Zarei B, Mousavi M, Mehdizadeh S, Mehrad-Majd H, Zarif M, Erfanian Z, Moradi A. Early effects of atorvastatin on Vitamin D and parathyroid hormone serum levels following acute myocardial infarction.J Res Pharm Pract 2019;8:7-12


How to cite this URL:
Zarei B, Mousavi M, Mehdizadeh S, Mehrad-Majd H, Zarif M, Erfanian Z, Moradi A. Early effects of atorvastatin on Vitamin D and parathyroid hormone serum levels following acute myocardial infarction. J Res Pharm Pract [serial online] 2019 [cited 2019 Jul 22 ];8:7-12
Available from: http://www.jrpp.net/article.asp?issn=2319-9644;year=2019;volume=8;issue=1;spage=7;epage=12;aulast=Zarei;type=0