Journal of Research in Pharmacy Practice

REVIEW ARTICLE
Year
: 2019  |  Volume : 8  |  Issue : 4  |  Page : 181--188

Clinical role of silymarin in oxidative stress and infertility: A short review for pharmacy practitioners


Morvarid Zarif-Yeganeh, Mansoor Rastegarpanah 
 Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Dr. Mansoor Rastegarpanah
Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran
Iran

Silymarin (SMN) as an ancient plant has various therapeutic usage in many diseases. Almost all of its properties attributed to antioxidant and anti-inflammatory properties. Currently, infertility problems impose a heavy burden on many developing countries. As a result, effective infertility treatment is indicated. The role of oxidative stress in both male and female infertility has been revealed. Many studies have shown protective and antioxidative properties of SMN against adverse effects of chemotherapy medications and environmental toxins in sperms and oocytes. The antioxidative and clinical role of SMN in infertility has been reviewed. The use of antioxidants such as SMN can help to improve fertility rate by scavenging free radicals and inhibiting nuclear factor kappa B transcription factor. Animal studies in both male and female have indicated a beneficial effect of SMN on fertility recovery. Further clinical studies are needed considering the phytoestrogenic property of SMN, to determine the right dose and duration of treatment.


How to cite this article:
Zarif-Yeganeh M, Rastegarpanah M. Clinical role of silymarin in oxidative stress and infertility: A short review for pharmacy practitioners.J Res Pharm Pract 2019;8:181-188


How to cite this URL:
Zarif-Yeganeh M, Rastegarpanah M. Clinical role of silymarin in oxidative stress and infertility: A short review for pharmacy practitioners. J Res Pharm Pract [serial online] 2019 [cited 2020 Feb 22 ];8:181-188
Available from: http://www.jrpp.net/article.asp?issn=2319-9644;year=2019;volume=8;issue=4;spage=181;epage=188;aulast=Zarif-Yeganeh;type=0