|
 
 |
| ORIGINAL ARTICLE |
|
| Year : 2016 | Volume
: 5
| Issue : 2 | Page : 94-100 |
|
Effect of high-dose Ascorbic acid on vasopressor's requirement in septic shock
Mohadeseh Hosseini Zabet1, Mostafa Mohammadi2, Masoud Ramezani2, Hossein Khalili1
1 Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Intensive Care Unit, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Date of Web Publication | 1-Apr-2016 |
Correspondence Address:
Hossein Khalili
Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2279-042X.179569
Objective: Effects of ascorbic acid on hemodynamic parameters of septic shock were evaluated in nonsurgical critically ill patients in limited previous studies. In this study, the effect of high-dose ascorbic acid on vasopressor drug requirement was evaluated in surgical critically ill patients with septic shock.
Methods: Patients with septic shock who required a vasopressor drug to maintain mean arterial pressure >65 mmHg were assigned to receive either 25 mg/kg intravenous ascorbic acid every 6 h or matching placebo for 72 h. Vasopressor dose and duration were considered as the primary outcomes. Duration of Intensive Care Unit (ICU) stay and 28-day mortality has been defined as secondary outcomes.
Findings: During the study period, 28 patients (14 in each group) completed the trial. Mean dose of norepinephrine during the study period (7.44 ± 3.65 vs. 13.79 ± 6.48 mcg/min, P = 0.004) and duration of norepinephrine administration (49.64 ± 25.67 vs. 71.57 ± 1.60 h, P = 0.007) were significantly lower in the ascorbic acid than the placebo group. No statistically significant difference was detected between the groups regarding the length of ICU stay. However, 28-day mortality was significantly lower in the ascorbic acid than the placebo group (14.28% vs. 64.28%, respectively; P = 0.009).
Conclusion: High-dose ascorbic acid may be considered as an effective and safe adjuvant therapy in surgical critically ill patients with septic shock. The most effective dose of ascorbic acid and the best time for its administration should be determined in future studies. Keywords: Ascorbic acid; norepinephrine; sepsis; shock; vasopressor
How to cite this article:
Zabet MH, Mohammadi M, Ramezani M, Khalili H. Effect of high-dose Ascorbic acid on vasopressor's requirement in septic shock. J Res Pharm Pract 2016;5:94-100 |
How to cite this URL:
Zabet MH, Mohammadi M, Ramezani M, Khalili H. Effect of high-dose Ascorbic acid on vasopressor's requirement in septic shock. J Res Pharm Pract [serial online] 2016 [cited 2023 Feb 8];5:94-100. Available from: https://www.jrpp.net/text.asp?2016/5/2/94/179569 |
| Introduction | |  |
Sepsis is a life-threatening systemic inflammatory response that can result in multi-organ dysfunction and intractable hypotension. [1] In critically ill patients, severe sepsis and septic shock are known as the main causes of mortality. [2] Adequate fluid resuscitation, infection control, cardiovascular and respiratory supports are recommended for the management of severe sepsis and septic shock. [3] Septic shock usually does not response to intravenous fluid resuscitation and most patients need a vasopressor drug administration. [1],[4],[5] Concomitant vasodilatation and reduced vascular response to the vasopressors have been detected in septic shock. [6],[7] Several mechanisms such as adrenal insufficiency, endothelial damage, oxidative stress, and depletion of catecholamine storage are proposed for vascular hyporesponsiveness to vasopressors in critically ill patients with septic shock. [8],[9],[10],[11]
Ascorbic acid (Vitamin C) is an essential nutrient with potent antioxidant properties. [12],[13] Ascorbic acid deficiency defined as serum ascorbic acid level <23 μmol/L has been reported in critically ill patients with acute respiratory infections and sepsis. [14],[15],[16] High-dose ascorbic acid improved edema and respiratory function in critically ill patients with severe burn injury and decreased organ failure and duration of Intensive Care Unit (ICU) stay in patients after major surgery. [17],[18]
Effects of ascorbic acid on hemodynamic parameters were evaluated in nonsurgical critically ill patients in limited previous studies. High-dose ascorbic acid in patients with burn injury decreased fluid and vasopressors' requirements. Also, in patients with severe sepsis, high-dose intravenous ascorbic acid improved hemodynamic parameters. [15],[17],[19],[20] Potential benefit of ascorbic acid in surgical critically ill patients with diagnosis of severe sepsis or septic shock has not yet been evaluated. In this study, the effects of high-dose ascorbic acid on vasopressor requirement were evaluated in surgical critically ill patients with septic shock.
| Methods | | |
This double-blinded randomized clinical trial was conducted in an ICU of Imam Khomeini Hospital, a referral general hospital affiliated to Tehran University of Medical Sciences, Tehran, Iran. This ICU has 18 beds and most of the beds are usually allocated for postoperative patients. The researchers, ICU nurses, and physicians were blinded regarding the intervention and the product (ascorbic acid or placebo) was prepared by Hospital Pharmacy Department. During the study period, from September 2014 to January 2016, 28 adult (18-65-year-old) surgical critically ill patients with diagnosis of septic shock who needed a vasopressor drug to maintain mean arterial pressure (MAP) >65 mmHg despite adequate fluid resuscitation were recruited. The sample size of the study was considered based on the ICU patients' turn-over and number of patients who were hospitalized with a diagnosis of septic shock during the same period in previous years.
Septic shock was defined based on the Surviving Sepsis Campaign and patients with the following criteria: (1) Presence of a systemic inflammatory response: (fever: T >38°C or hypothermia: T <36°C, heart rate >90 beats/min, leukocytosis or leukopenia (white blood cell >12,000/μL and <4000/μL, respectively, or >10% band forms), (2) suspected or proven infection, (3) presence of sepsis-induced organ dysfunction (arterial hypoxemia [PaO 2 /FiO 2 <300], systolic blood pressure [SBP] <90 mmHg, or SBP decrease >40 mmHg unexplained by other causes), urine output <0.5 ml/kg/h for >6 h despite fluid resuscitation, platelet count <100,000/μL, acutely developing coagulopathy (international normalized ratio >1.5), serum bilirubin concentration >2 mg/dL were considered for enrollment [3] Concomitant use of other antioxidants (such as Vitamin E, selenium, and N-acetylcysteine), corticosteroids administration, any contraindication for high-dose ascorbic acid including bilateral ureteric obstruction, chronic hemodialysis, iron overload, oxalate stone formers, [21] hemochromatosis, and glucose-6-phosphate dehydrogenase deficiency [22] were defined as exclusions.
Ethical Committee of the hospital approved the study protocol and the patients or one of their first-degree family members signed the study's informed consent form.
Treatment of septic shock in the ICU was based on the Surviving Sepsis Campaign recommendations. [3] Fluid resuscitation strategy was the administration of a crystalloid solution (0.9% saline) to maintain central venous pressure >12 mmHg. In patients who had MAP <65 mmHg despite adequate fluid administration for 6 h, a vasopressor drug (norepinephrine) was started. Norepinephrine was started with a dose of 5 mcg/min and was titrated based on the patient's hemodynamic status, up to 30 mcg/min. Antibiotic regimens were guided based on the hospital recommendations. Stress ulcer prophylaxis (pantoprazole 40 mg daily as intravenous injection) and deep venous thrombosis prophylaxis (heparin 5000 IU every 8 h as subcutaneous injection) were considered for all patients. Analgosedation (fentanyl as continuous intravenous infusion) was the sedation protocol in our center.
The patients were included in ascorbic acid or placebo group according to the permuted block randomization. The randomization scheme consisted of seven blocks and each block contained four patients in random order. Patients in the ascorbic acid group received 25 mg/kg intravenous ascorbic acid every 6 h for 72 h. The dose and duration of intervention were selected based on the literature review. [15],[17],[19],[20] Each dose of ascorbic acid was diluted in 50 ml of dextrose 5% solution and was administered as intravenous infusion over 30 min. Patients in the placebo group received 50 ml of dextrose 5% solution as intravenous infusion over 30 min.
The patients' demographic data (including age, sex, baseline diseases, and causes of ICU admission) were extracted from their medical charts, and the patients' clinical characteristics (such as vital signs and hemodynamic parameters) were monitored as daily interval. Laboratory data such as serum electrolyte concentrations, blood urea nitrogen (BUN), and serum creatinine levels were extracted from the patients' medical charts. The patients' Acute Physiology and Chronic Health Evaluation II (APACHE II) and sequential organ failure assessment (SOFA) scores were calculated at the time of recruitment.
Change in the hemodynamic parameters (MAP and pulse rate), oxygenation status (respiratory rate, oxygen saturation, duration of mechanical ventilation, pH, and PaO 2 /FiO 2 ratio), fluid intake, renal function (BUN, serum creatinine, and urine output), and serum electrolytes during the study period were compared between the groups.
Vasopressor dose and duration were evaluated on a daily basis for 3 days and were considered as the primary outcomes. Duration of ICU stay and 28-day mortality has been defined as secondary outcomes.
During the study period, patients were followed for any ascorbic acid-related adverse effects including nausea, vomiting, abdominal pain, hematuria, flushing, and significant arterial blood pressure change.
Data were analyzed using SPSS software version 17 (SPSS Inc., Chicago, USA). The Kolmogorov-Smirnov test was used to assess the normal distribution of continuous variables. Normally distributed continuous data were expressed as mean ± standard deviation. Categorical variables were reported as percentages. Chi-square or Fisher's exact test was used for comparing the categorical variables between the groups. Continuous variables were compared by the independent t-test. Mortality rate was compared between the groups using Chi-square test. Changes in the hemodynamic, oxygenation, and electrolyte parameters during the study period were assessed using one-way analysis of variance with repeated measure. P < 0.05 was defined as statistically significant.
| Results | | |
During the study period, 28 patients (14 in each group) were recruited. No patient was excluded during 3-day intervention. Demographic and clinical characteristics of the recruited patients are shown in [Table 1]. From the participants, 71.42% and 78.57% in the ascorbic acid and control groups were male, respectively. Included subjects were admitted to the ICU following gastrointestinal surgeries. No statistically significant difference was detected between the groups in terms of demographic data and clinical characteristics. Severity of illnesses based on the SOFA and APACHE II scores was comparable between the groups at the time of enrollment.
Hemodynamic parameters and laboratory tests did not differ significantly between the groups. In addition, changes in these parameters during the study period were not statistically significant. Data regarding these parameters are shown in [Table 2] and [Table 3].
Mean dose of vasopressor (norepinephrine) during the study period (7.44 ± 3.65 vs. 13.79 ± 6.48 mcg/min, P = 0.004), mean dose of norepinephrine in the first 24 h of enrollment (6.51 ± 3.53 vs. 12.58 ± 5.99 mcg/min, P = 0.003), total dose of norepinephrine in the first 24 h (156.42 ± 84.81 vs. 302.14 ± 143.85 mcg, P = 0.003), and duration of receiving norepinephrine (49.64 ± 25.67 vs. 71.57 ± 1.60 h, P = 0.007) were significantly lower in the ascorbic acid than the placebo group [Table 4]. | Table 4: Primary and secondary outcomes of the study in ascorbic and placebo groups
Click here to view |
No statistically significant difference was detected between the groups regarding the length of ICU stay. However, the 28-day mortality was significantly lower in the ascorbic acid than the placebo group (14.28% vs. 64.28%, respectively; P = 0.009).
No ascorbic acid-related adverse events were identified in the treatment group during the study.
| Discussion | | |
In this study, administration of high-dose ascorbic acid significantly decreased the requirement for vasopressor's dose and duration in surgical critically ill patients with septic shock. Several mechanisms including anti-oxidant, anti-inflammatory, nitric oxide (NO) synthase inhibitory, reversing vascular hyporesponsiveness to vasopressors, increasing catecholamines and cortisol synthesis in adrenal medulla, and improving vascular endothelium integrity properties may justified the role of ascorbic acid in septic shock. [8],[9],[10],[11],[15],[18],[23],[24]
Severe ascorbic acid deficiency (serum ascorbate level <27 μmol/L) was reported in critically ill patients. [15],[16],[25],[26],[27] Up to 3000 mg/day, ascorbic acid was needed to normalize the plasma level of ascorbic acid (68 μmol/L) in these patients. [28] Ascorbic acid deficiency was not prevented by the use of parenteral nutrition containing ascorbic acid in critically ill patients and most patients required high dose of this nutrient. [29],[30],[31],[32]
Catecholamines (dopamine, norepinephrine, and epinephrine) are produced by sympathetic nervous system and adrenal medulla. [33] Brain and adrenal glands have the highest levels of ascorbic acid in the body. [34] In catecholamine synthesis pathway, ascorbic acid is an essential cofactor for the copper-containing enzyme; dopamine β-hydroxylase. [35],[36] This enzyme has a critical role in norepinephrine synthesis from dopamine. Ascorbic acid deficiency was associated with decreased level of norepinephrine, especially in the adrenal glands. [37],[38],[39] Insufficiency in adrenal hormone synthesis has also been observed in critically ill patients. [40],[41]
Vasopressin is a peptide hormone that is synthesized form a preprohormone in the hypothalamus and stored in the posterior pituitary gland. [42] It is secreted following blood volume and arterial pressure dropping or plasma osmolality raising, attaches to vascular smooth muscle cells (AVPR 1a ), and kidney-collecting ducts (AVPR 2 ), receptors, and consequently induces vasoconstriction and water retention. [43] A significant increase in the vasopressin level was detected during the initial phase of septic shock. However, in the later phase, it decreased dramatically. [6],[44] The decrease in circulating vasopressin level is due to the depletion of pituitary storage and its synthesis. [7] Peptidylglycine α-amidating monooxygenase, a copper-containing enzyme with ascorbic acid cofactor, is essential for endogenous synthesis of vasopressin. [45] Decreasing activity of this enzyme during sepsis period may limit vasopressin synthesis. [7],[44],[46] Correlation between ascorbic acid deficiency and vasopressin insufficiency has been reported in critically ill patients. [26] Administration of ascorbic acid enhanced the circulating level of vasopressin. [47]
Septic shock is characterized by decreased peripheral vascular resistance and impaired blood and oxygen supply to the body's vital organs. A combination of vasodilatation and pronounced decrease in vascular response to vasopressor including high-dose norepinephrine often results in resistant hypotension. [6],[46] Overproduction of NO appears to be an important mechanism in septic shock, and inhibition of NO synthase might provide a novel therapeutic approach. In 1991, Petros et al. [8] assessed the effects of NO synthase inhibitors in two patients with life-threatening and unresponsive septic shock. NG monomethyl-L-arginine (L-NMMA) caused dose-dependent increase in blood pressure and systemic vascular resistance in both patients, and a similar effect was observed in the second patient after treatment with NG-nitro-L-arginine methyl ester. In another study, L-NMMA increased vascular tone and raised blood pressure in 12 patients with septic shock. [9] Furthermore, methylene blue as a guanylate cyclase and NO synthase inhibitor increased arterial blood pressure and improved cardiac function in septic patients. [10],[11]
Intravenous ascorbic acid improved cardiovascular functioning and decreased requirement for catecholamine administration in a patient with septic shock. [25] In another case with typical symptoms of scurvy and fluid-resistant severe orthostatic hypotension, intravenous ascorbic acid improved the patients' hemodynamic status within 24 h after its administration.
Inflammatory cascades and release of inflammatory cytokines are from known pathways in the pathogenesis of sepsis. [26] Administration of high-dose intravenous ascorbic acid to severely affected patients with burn injury decreased the fluid and vasopressors requirements. [17],[48] In a recent phase I, randomized controlled trial in 24 patients with severe sepsis, intravenous infusions of high-dose ascorbic acid (200 mg/kg/24 h) caused rapid reduction in SOFA score and improvement in hemodynamic parameters. Vascular endothelial repair following reduction in the proinflammatory biomarkers including C-reactive protein and procalcitonin as well as reduction of thrombomodulin level was suggested for ascorbic acid. [15],[49]
Anti-oxidant property may be responsible for some beneficial effects of ascorbic acid in severe sepsis and septic shock. Early administration of antioxidants; α-tocopherol, 1000 IU every 8 h and ascorbic acid 1000 mg intravenously in 100 ml D5W every 8 h for a short duration, reduced the incidence of organ failure and ICU length of stay in critically ill surgical patients. [18] Administration of Vitamin C augmented the inotropic response to dobutamine in human subjects who were selected for elective diagnostic heart catheterization. Redox-regulated pathways of adrenergic system and ventricular contractility may be responsible for this effect of ascorbic acid. [23]
Corticosteroids have an important position in preventing beta adrenergic receptors' down-regulation and maintaining vasopressors' responsiveness of the vascular bed in septic shock. [11] Cortisol-sparing effect of ascorbic acid has been reported. Vitamin C significantly prevented etomidate-induced adrenal insufficiency and serum cortisol depletion. [24]
Ascorbic acid is a safe anti-oxidant nutrient and no any considerable adverse event has been reported yet, even after high-dose administration. In Nathens et al. study, critically ill surgical patients tolerated ascorbic acid, 1 g every 8 h for 28 days, without any adverse effect. [18] In addition, no adverse event was detected in critically ill patients with burn injury who received ascorbic acid with a dose of 66 mg/kg/h for 24 h. [17] Aggressive repletion of plasma ascorbic acid level was safe in patients with severe sepsis. No patient with the low (50 mg/kg/24 h) or high (200 mg/kg/24 h) dose of ascorbic acid experienced any identifiable ascorbic acid-related adverse event. [15] Similar to previous studies, we did not detect any ascorbic acid-related adverse events in the included patients.
Fluid resuscitation, vasopressor therapy, and ventilation supports are cornerstones of severe sepsis and septic shock management. Although oxygenation status, duration of mechanical ventilation, and hemodynamic parameters were comparable between the two groups in our study, for targeting these points, patients in the placebo group needed higher dose and longer duration of vasopressor therapy.
Although the results of our study are promising, the study suffers from some limitations. Small sample size, short period of intervention, and no assessment of the patients' serum ascorbate baseline level are the major limitations of our study. Further randomized controlled trials with sufficient sample size and assessment of baseline serum ascorbate level, serum antioxidant capacity, and proinflammatory cytokines may be considered in future studies.
Our results suggested that high-dose of ascorbic acid (25 mg/kg intravenously every 6 h for 72 h) with its probable anti-oxidant, anti-inflammatory, cortisol sparing, NO synthase inhibitory and increasing catecholamines synthesis in the brain, and adrenal medulla properties may be considered as an effective and safe adjuvant therapy in critically ill surgical patients with septic shock. However, as limited evidences are now available, the most effective dose of ascorbic acid and the best time for its administration should be determined in future studies.
| Authors' Contribution | | |
MH: Data gathering and primary drafting of the manuscript, MM: Clinical evaluation of the patients, MR: Controlling of the patients' medications and hemodynamic assessment, HK: Designing of the study and editing the manuscript.
Acknowledgments
This study was the result of a Pharm.D student thesis. The authors expressed sincere gratitude to all the nursing staff of general ICU of Imam Khomeini Hospital for their kind support.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
| References | | |
| 1. | Remick DG. Pathophysiology of sepsis. Am J Pathol 2007;170:1435-44.  |
| 2. | Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003. Crit Care Med 2007;35:1244-50. |
| 3. | Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013;39:165-228. [ PUBMED] |
| 4. | Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med 2013;369:840-51. |
| 5. | Vasu TS, Cavallazzi R, Hirani A, Kaplan G, Leiby B, Marik PE. Norepinephrine or dopamine for septic shock: Systematic review of randomized clinical trials. J Intensive Care Med 2012;27:172-8. |
| 6. | Landry DW, Levin HR, Gallant EM, Seo S, D'Alessandro D, Oz MC, et al. Vasopressin pressor hypersensitivity in vasodilatory septic shock. Crit Care Med 1997;25:1279-82. |
| 7. | Sharshar T, Carlier R, Blanchard A, Feydy A, Gray F, Paillard M, et al. Depletion of neurohypophyseal content of vasopressin in septic shock. Crit Care Med 2002;30:497-500. |
| 8. | Petros A, Bennett D, Vallance P. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 1991;338:1557-8. |
| 9. | Petros A, Lamb G, Leone A, Moncada S, Bennett D, Vallance P. Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc Res 1994;28:34-9. |
| 10. | Preiser JC, Lejeune P, Roman A, Carlier E, De Backer D, Leeman M, et al. Methylene blue administration in septic shock: A clinical trial. Crit Care Med 1995;23:259-64. |
| 11. | O'Brien A, Clapp L, Singer M. Terlipressin for norepinephrine-resistant septic shock. Lancet 2002;359:1209-10. [ PUBMED] |
| 12. | Carr A, Frei B. Does Vitamin C act as a pro-oxidant under physiological conditions? FASEB J 1999;13:1007-24. |
| 13. | Carr AC, Frei B. Toward a new recommended dietary allowance for Vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr 1999;69:1086-107. |
| 14. | Hunt C, Chakravorty NK, Annan G, Habibzadeh N, Schorah CJ. The clinical effects of Vitamin C supplementation in elderly hospitalised patients with acute respiratory infections. Int J Vitam Nutr Res 1994;64:212-9. |
| 15. | Fowler AA 3 rd , Syed AA, Knowlson S, Sculthorpe R, Farthing D, DeWilde C, et al. Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med 2014;12:32. |
| 16. | Schorah CJ, Downing C, Piripitsi A, Gallivan L, Al-Hazaa AH, Sanderson MJ, et al. Total Vitamin C, ascorbic acid, and dehydroascorbic acid concentrations in plasma of critically ill patients. Am J Clin Nutr 1996;63:760-5. |
| 17. | Tanaka H, Matsuda T, Miyagantani Y, Yukioka T, Matsuda H, Shimazaki S. Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: A randomized, prospective study. Arch Surg 2000;135:326-31. |
| 18. | Nathens AB, Neff MJ, Jurkovich GJ, Klotz P, Farver K, Ruzinski JT, et al. Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Ann Surg 2002;236:814-22. |
| 19. | Wilson JX. Evaluation of Vitamin C for adjuvant sepsis therapy. Antioxid Redox Signal 2013;19:2129-40. |
| 20. | Oudemans-van Straaten HM, Spoelstra-de Man A, de Waard MC. Vitamin C revisited. Crit Care Med 2014;18:460. |
| 21. | Riordan HD, Hunninghake RB, Riordan NH, Jackson JJ, Meng X, Taylor P, et al. Intravenous ascorbic acid: Protocol for its application and use. P R Health Sci J 2003;22:287-90. |
| 22. | Hoffer LJ, Levine M, Assouline S, Melnychuk D, Padayatty SJ, Rosadiuk K, et al. Phase I clinical trial of i.v. ascorbic acid in advanced malignancy. Ann Oncol 2008;19:1969-74. |
| 23. | Mak S, Newton GE. Vitamin C augments the inotropic response to dobutamine in humans with normal left ventricular function. Circulation 2001;103:826-30. |
| 24. | Nooraee N, Fathi M, Edalat L, Behnaz F, Mohajerani SA, Dabbagh A. Effect of Vitamin C on serum cortisol reduction after etomidate induction of anesthesia. J Cell Mol Anesth 2015;1:28-33. |
| 25. | Kieffer P, Thannberger P, Wilhelm JM, Kieffer C, Schneider F. Multiple organ dysfunction dramatically improving with the infusion of Vitamin C: More support for the persistence of scurvy in our "welfare" society. Intensive Care Med 2001;27:448. [ PUBMED] |
| 26. | Zipursky JS, Alhashemi A, Juurlink D. A rare presentation of an ancient disease: Scurvy presenting as orthostatic hypotension. BMJ Case Rep 2014;2014. pii: Bcr2013201982. |
| 27. | Holley AD, Osland E, Barnes J, Krishnan A, Fraser JF. Scurvy: Historically a plague of the sailor that remains a consideration in the modern intensive care unit. Intern Med J 2011;41:283-5. |
| 28. | Long CL, Maull KI, Krishnan RS, Laws HL, Geiger JW, Borghesi L, et al. Ascorbic acid dynamics in the seriously ill and injured. J Surg Res 2003;109:144-8. |
| 29. | 29 Fukushima R, Yamazaki E. Vitamin C requirement in surgical patients. Curr Opin Clin Nutr Metab Care 2010;13:669-76. |
| 30. | Crandon JH, Landau B, Mikal S, Balmanno J, Jefferson M, Mahoney N. Ascorbic acid economy in surgical patients as indicated by blood ascorbic acid levels. N Engl J Med 1958;258:105-13. [ PUBMED] |
| 31. | Kirkemo AK, Burt ME, Brennan MF. Serum Vitamin level maintenance in cancer patients on total parenteral nutrition. Am J Clin Nutr 1982;35:1003-9. [ PUBMED] |
| 32. | Lowry SF, Goodgame JT Jr., Maher MM, Brennan MF. Parenteral Vitamin requirements during intravenous feeding. Am J Clin Nutr 1978;31:2149-58. |
| 33. | De Backer D, Scolletta S. Clinical management of the cardiovascular failure in sepsis. Curr Vasc Pharmacol 2013;11:222-42. |
| 34. | Hornig D. Distribution of ascorbic acid, metabolites and analogues in man and animals. Ann N Y Acad Sci 1975;258:103-18. [ PUBMED] |
| 35. | May JM, Qu ZC, Nazarewicz R, Dikalov S. Ascorbic acid efficiently enhances neuronal synthesis of norepinephrine from dopamine. Brain Res Bull 2013;90:35-42. |
| 36. | Levine M. Ascorbic acid specifically enhances dopamine beta-monooxygenase activity in resting and stimulated chromaffin cells. J Biol Chem 1986;261:7347-56. [ PUBMED] |
| 37. | Deana R, Bharaj BS, Verjee ZH, Galzigna L. Changes relevant to catecholamine metabolism in liver and brain of ascorbic acid deficient guinea-pigs. Int J Vitam Nutr Res 1975;45:175-82. [ PUBMED] |
| 38. | Hoehn SK, Kanfer JN. Effects of chronic ascorbic acid deficiency on guinea pig lysosomal hydrolase activities. J Nutr 1980;110:2085-94. [ PUBMED] |
| 39. | Bornstein SR, Yoshida-Hiroi M, Sotiriou S, Levine M, Hartwig HG, Nussbaum RL, et al. Impaired adrenal catecholamine system function in mice with deficiency of the ascorbic acid transporter (SVCT2). FASEB J 2003;17:1928-30. |
| 40. | Duggan M, Browne I, Flynn C. Adrenal failure in the critically ill. Br J Anaesth 1998;81:468-70. |
| 41. | Nieboer P, van der Werf TS, Beentjes JA, Tulleken JE, Zijlstra JG, Ligtenberg JJ. Catecholamine dependency in a polytrauma patient: Relative adrenal insufficiency? Intensive Care Med 2000;26:125-7. |
| 42. | Treschan TA, Peters J. The vasopressin system: Physiology and clinical strategies. Anesthesiology 2006;105:599-612. |
| 43. | Russell JA. Bench-to-bedside review: Vasopressin in the management of septic shock. Crit Care Med 2011;15:226. |
| 44. | Sharshar T, Blanchard A, Paillard M, Raphael JC, Gajdos P, Annane D. Circulating vasopressin levels in septic shock. Crit Care Med 2003;31:1752-8. |
| 45. | Prigge ST, Mains RE, Eipper BA, Amzel LM. New insights into copper monooxygenases and peptide amidation: Structure, mechanism and function. Cell Mol Life Sci 2000;57:1236-59. |
| 46. | Landry DW, Levin HR, Gallant EM, Ashton RC Jr., Seo S, D'Alessandro D, et al. Vasopressin deficiency contributes to the vasodilation of septic shock. Circulation 1997;95:1122-5. |
| 47. | Giusti-Paiva A, Domingues VG. Centrally administered ascorbic acid induces antidiuresis, natriuresis and neurohypophyseal hormone release in rats. Neuro Endocrinol Lett 2010;31:87-91. |
| 48. | Kahn SA, Beers RJ, Lentz CW. Resuscitation after severe burn injury using high-dose ascorbic acid: A retrospective review. J Burn Care Res 2011;32:110-7. |
| 49. | Morelli A, Ertmer C, Rehberg S, Lange M, Orecchioni A, Laderchi A, et al. Phenylephrine versus norepinephrine for initial hemodynamic support of patients with septic shock: A randomized, controlled trial. Crit Care Med 2008;12:R143. |
[Table 1], [Table 2], [Table 3], [Table 4]
| This article has been cited by | | 1 |
IV Vitamin C in Sepsis: A Latest Systematic Review and Meta-Analysis |
|
| Chengli Wen, Yuan Li, Qinxue Hu, Hui Liu, Xinxin Xu, Muhan Lü, Ahmed Abdelwahab | | International Journal of Clinical Practice. 2023; 2023: 1 | | [Pubmed] | [DOI] | | | 2 |
An update of the effects of vitamins D and C in critical illness |
|
| Aileen Hill, Christina Starchl, Ellen Dresen, Christian Stoppe, Karin Amrein | | Frontiers in Medicine. 2023; 9 | | [Pubmed] | [DOI] | | | 3 |
The effect of intravenous vitamin C on clinical outcomes in patients with sepsis or septic shock: A meta-analysis of randomized controlled trials |
|
| Huiyan Zhu, Xiaoya Xu, Kai Zhang, Qiaoping Ye | | Frontiers in Nutrition. 2022; 9 | | [Pubmed] | [DOI] | | | 4 |
Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice |
|
| Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Takashi Ito, Satoshi Hara, Hiroshi Ichinose, Yasuyuki Kakihana | | Frontiers in Pharmacology. 2022; 13 | | [Pubmed] | [DOI] | | | 5 |
An update in the utilization of N-acetyl cysteine & vitamin c for tackling the oxidative stress in acute kidney injury secondary to robust sepsis - A systematic review |
|
| Kaur Kulvinder Kochar, Allahbadia Gautam , Singh Mandeep | | Journal of Clinical Nephrology. 2022; 6(1): 001 | | [Pubmed] | [DOI] | | | 6 |
Kinetics of Biomarkers of Oxidative Stress in Septic Shock: A Pilot Study |
|
| Martin Helan, Jan Malaska, Josef Tomandl, Jiri Jarkovsky, Katerina Helanova, Klara Benesova, Michal Sitina, Milan Dastych, Tomas Ondrus, Monika Pavkova Goldbergova, Roman Gal, Petr Lokaj, Marie Tomandlova, Jiri Parenica | | Antioxidants. 2022; 11(4): 640 | | [Pubmed] | [DOI] | | | 7 |
Vitamin C Deficiency in Blood Samples of COVID-19 Patients |
|
| Tobias Sinnberg, Christa Lichtensteiger, Katharina Hill-Mündel, Christian Leischner, Heike Niessner, Christian Busch, Olga Renner, Nina Wyss, Lukas Flatz, Ulrich M. Lauer, Ludwig E. Hoelzle, Donatus Nohr, Markus Burkard, Luigi Marongiu, Sascha Venturelli | | Antioxidants. 2022; 11(8): 1580 | | [Pubmed] | [DOI] | | | 8 |
The Role and Efficacy of Vitamin C in Sepsis: A Systematic Review and Meta-Analysis |
|
| Marwah Muhammad, Ahmad Jahangir, Ali Kassem, Saud Bin Abdul Sattar, Abdullah Jahangir, Syeda Sahra, Muhammad Rafay Khan Niazi, Ahmad Mustafa, Zeeshan Zia, Fasih Sami Siddiqui, Waleed Sadiq, Danil Mishiyev, Aleena Sammar, Loai Dahabra, Aazib Irshad, Dany Elsayegh, Michel Chalhoub | | Advances in Respiratory Medicine. 2022; 90(4): 281 | | [Pubmed] | [DOI] | | | 9 |
Potential Antioxidant Multitherapy against Complications Occurring in Sepsis |
|
| Joaquin Abelli, Gabriel Méndez-Valdés, Francisca Gómez-Hevia, Maria Chiara Bragato, Silvia Chichiarelli, Luciano Saso, Ramón Rodrigo | | Biomedicines. 2022; 10(12): 3088 | | [Pubmed] | [DOI] | | | 10 |
High-Dose Intravenous Ascorbate in Sepsis, a Pro-Oxidant Enhanced Microbicidal Activity and the Effect on Neutrophil Functions |
|
| Kritsanawan Sae-khow, Awirut Charoensappakit, Direkrit Chiewchengchol, Asada Leelahavanichkul | | Biomedicines. 2022; 11(1): 51 | | [Pubmed] | [DOI] | | | 11 |
Bias against Vitamin C in Mainstream Medicine: Examples from Trials of Vitamin C for Infections |
|
| Harri Hemilä, Elizabeth Chalker | | Life. 2022; 12(1): 62 | | [Pubmed] | [DOI] | | | 12 |
The Mutual Relationship among Cardiovascular Diseases and COVID-19: Focus on Micronutrients Imbalance |
|
| Paolo Severino, Andrea D’Amato, Silvia Prosperi, Vincenzo Myftari, Aurora Labbro Francia, Merve Önkaya, Claudia Notari, Ilaria Papisca, Elena Sofia Canuti, Mia Yarden Revivo, Lucia Ilaria Birtolo, Paola Celli, Gioacchino Galardo, Viviana Maestrini, Gabriella d’Ettorre, Massimo Mancone, Francesco Fedele | | Nutrients. 2022; 14(16): 3439 | | [Pubmed] | [DOI] | | | 13 |
Oxygen therapy for sepsis and prevention of complications |
|
| Hayk Minasyan | | Acute and Critical Care. 2022; 37(2): 137 | | [Pubmed] | [DOI] | | | 14 |
Efficacy of High-Dose Vitamin C Infusion on Outcomes in Sepsis Requiring Mechanical Ventilation: A Double-Blind Randomized Controlled Trial |
|
| Wessam A. El Driny, Ibrahim M. Esmat, Sara M. Shaheen, Nagwa A. Sabri, Basavana B. Goudra | | Anesthesiology Research and Practice. 2022; 2022: 1 | | [Pubmed] | [DOI] | | | 15 |
Intravenous vitamin C administration to patients with septic shock: a pilot randomised controlled trial |
|
| Patrice Rosengrave, Emma Spencer, Jonathan Williman, Jan Mehrtens, Stacey Morgan, Tara Doyle, Kymbalee Van Der Heyden, Anna Morris, Geoff Shaw, Anitra C. Carr | | Critical Care. 2022; 26(1) | | [Pubmed] | [DOI] | | | 16 |
Vitamin C therapy in septic shock |
|
| Syed Nabeel Muzaffar, Sai Saran, Suhail Sarwar Siddiqui | | Critical Care. 2022; 26(1) | | [Pubmed] | [DOI] | | | 17 |
The revised recommendation for administering vitamin C in septic patients: the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 |
|
| Moritoki Egi, Hiroshi Ogura | | Journal of Intensive Care. 2022; 10(1) | | [Pubmed] | [DOI] | | | 18 |
Analysis of Efficacy of Ascorbic Acid, Hydrocortisone and Thiamine as a Part Adjuvant Therapy of Sepsis and Septic Shock |
|
| L. L. Plotkin, V. A. Artamonov | | Messenger of ANESTHESIOLOGY AND RESUSCITATION. 2022; 19(5): 102 | | [Pubmed] | [DOI] | | | 19 |
Lessening Organ dysfunction with VITamin C (LOVIT): statistical analysis plan (Preprint) |
|
| Neill KJ Adhikari, Ruxandra Pinto, Andrew G Day, Marie-Hélène Masse, Julie Ménard, Sheila Sprague, Djillali Annane, Yaseen M Arabi, Marie-Claude Battista, Dian Cohen, Deborah J Cook, Gordon H Guyatt, Daren K Heyland, Salmaan Kanji, Shay P McGuinness, Rachael L Parke, Bharath Kumar Tirupakuzhi Vijayaraghavan, Emmanuel Charbonney, Michael Chassé, Lorenzo Del Sorbo, Demetrios James Kutsogiannis, Francois Lauzier, Remi Leblanc, David M Maslove, Sangeeta Mehta, Armand Mekontso Dessap, Tina S Mele, Bram Rochwerg, Oleksa G Rewa, Jason Shahin, Pawel Twardowski, Paul Jeffrey Young, François Lamontagne | | JMIR Research Protocols. 2022; | | [Pubmed] | [DOI] | | | 20 |
History of scurvy and use of vitamin C in critical illness: A narrative review |
|
| Ellen Dresen, Zheng-Yii Lee, Aileen Hill, Quirin Notz, Jayshil J. Patel, Christian Stoppe | | Nutrition in Clinical Practice. 2022; | | [Pubmed] | [DOI] | | | 21 |
Vitamin C-based regimens for sepsis and septic shock: Systematic review and meta-analysis of randomized clinical trials. |
|
| Ana Luiza Cabrera Martimbianco, Rafael Leite Pacheco, Ângela Maria Bagattini, Roberta de Fátima Carreira Moreira Padovez, Luciano Cesar Pontes Azevedo, Rachel Riera | | Journal of Critical Care. 2022; 71: 154099 | | [Pubmed] | [DOI] | | | 22 |
Critically ill septic patients have elevated oxidative stress biomarkers: lack of attenuation by parenteral vitamin C |
|
| Emma Vlasiuk, Patrice Rosengrave, Ella Roberts, Joseph M. Boden, Geoff Shaw, Anitra C. Carr | | Nutrition Research. 2022; | | [Pubmed] | [DOI] | | | 23 |
Abrupt termination of vitamin C from ICU patients may increase mortality: secondary analysis of the LOVIT trial |
|
| Harri Hemilä, Elizabeth Chalker | | European Journal of Clinical Nutrition. 2022; | | [Pubmed] | [DOI] | | | 24 |
Plasma Ascorbic Acid Levels in Critically Ill Pediatric Patients |
|
| Daniel Horim Choi, Sonali Basu, Mark Levine, David Steinhorn | | Journal of Pediatric Intensive Care. 2022; | | [Pubmed] | [DOI] | | | 25 |
Parenteral Vitamin C in Patients with Severe Infection: A Systematic Review |
|
| Arnav Agarwal, John Basmaji, Shannon M. Fernando, Fang Zhou Ge, Yingqi Xiao, Haseeb Faisal, Kimia Honarmand, Mathieu Hylands, Vincent Lau, Kimberley Lewis, Rachel Couban, François Lamontagne, Neill K. J. Adhikari | | NEJM Evidence. 2022; | | [Pubmed] | [DOI] | | | 26 |
Evaluating Vitamin C in Septic Shock: A Randomized Controlled Trial of Vitamin C Monotherapy* |
|
| David A. Wacker, Susan L. Burton, John P. Berger, A. J. Hegg, Jamie Heisdorffer, Qi Wang, Emily J. Medcraft, Ronald A. Reilkoff | | Critical Care Medicine. 2022; 50(5): e458 | | [Pubmed] | [DOI] | | | 27 |
No benefit of hydrocortisone, ascorbic acid, and thiamine in reducing mortality in adult sepsis patients: a systematic review and meta-analysis |
|
| Qing Zhao, Jianguo Xiao, Hui Liu | | Emergency and Critical Care Medicine. 2022; Publish Ah | | [Pubmed] | [DOI] | | | 28 |
Beneficios del uso de las nuevas terapias con ácido ascórbico en los pacientes con sepsis |
|
| Razek Sayegh Kabbabe, Michael Schachter Reyes | | Revista de la Facultad de Medicina de la Universidad de lberoamérica. 2022; 2(2): 54 | | [Pubmed] | [DOI] | | | 29 |
A Systematic Review and Meta-Analysis on Possible Role of Vitamin C in Sepsis |
|
| Jonathan Brown, Cassie Robertson, Luis Sevilla, Jorge Garza, Hytham Rashid, Ana C Benitez, Mikhail Shipotko, Zuhair Ali | | Cureus. 2022; | | [Pubmed] | [DOI] | | | 30 |
Vitamin C and corticosteroids in viral pneumonia |
|
| Matthew Harry Anstey,Jacky Luu,Erina Myers,Robert N Palmer,Bradley Wibrow,Kwok M Ho | | Acute and Critical Care. 2021; 36(2): 169 | | [Pubmed] | [DOI] | | | 31 |
Potential benefit of high-dose intravenous vitamin C for coronavirus disease 2019 pneumonia |
|
| Bing Zhao, Meng-Jiao Li, Yun Ling, Yi-Bing Peng, Jun Huang, Hong-Ping Qu, Yuan Gao, Ying-Chuan Li, Bi-Jie Hu, Shui-Hua Lu, Hong-Zhou Lu, Wen-Hong Zhang, En-Qiang Mao | | Chinese Medical Journal. 2021; Publish Ah | | [Pubmed] | [DOI] | | | 32 |
Vitamin C for Sepsis and Septic Shock |
|
| Mahmoud A. Ammar, Abdalla A. Ammar, Melanie S. Condeni, Carolyn M. Bell | | American Journal of Therapeutics. 2021; 28(6): e649 | | [Pubmed] | [DOI] | | | 33 |
Vitamin C, Quo Vadis?* |
|
| L. Nelson Sanchez-Pinto,Eric L. Wald | | Pediatric Critical Care Medicine. 2021; 22(6): 588 | | [Pubmed] | [DOI] | | | 34 |
Adjunctive treatments for the management of septic shock – a narrative review of the current evidence |
|
| K. Donovan,A. Shah,J. Day,S. R. McKechnie | | Anaesthesia. 2021; | | [Pubmed] | [DOI] | | | 35 |
Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID-19 |
|
| Clive N. May,Rinaldo Bellomo,Yugeesh R. Lankadeva | | British Journal of Pharmacology. 2021; | | [Pubmed] | [DOI] | | | 36 |
A prospective, randomised clinical study comparing triple therapy regimen to hydrocortisone monotherapy in reducing mortality in septic shock patients |
|
| Abdelrhman A. Hussein,Nirmeen A. Sabry,Maged S. Abdalla,Samar F. Farid | | International Journal of Clinical Practice. 2021; | | [Pubmed] | [DOI] | | | 37 |
Effect of high-dose intravenous vitamin c on point-of-care blood glucose level in septic patients: a retrospective, single-center, observational case series |
|
| Juan He,Guanhao Zheng,Xian Qian,Huiqiu Sheng,Bing Chen,Bing Zhao,Erzhen Chen,Enqiang Mao,Xiaolan Bian | | Current Medical Research and Opinion. 2021; : 1 | | [Pubmed] | [DOI] | | | 38 |
Combination therapy of thiamine, vitamin C and hydrocortisone in treating patients with sepsis and septic shock: a meta-analysis and trial sequential analysis |
|
| Renqi Yao, Yibing Zhu, Yue Yu, Zhixuan Li, Lixue Wang, Liyu Zheng, Jingyan Li, Huibin Huang, Guosheng Wu, Feng Zhu, Zhaofan Xia, Chao Ren, Yongming Yao | | Burns & Trauma. 2021; 9 | | [Pubmed] | [DOI] | | | 39 |
Vitamin C-Induced Oxalate Nephropathy in a Septic Patient |
|
| Tasheen Wissanji,Marie-Eve Dupuis,Virginie Royal,Vincent Pichette,Han Ting Wang | | Critical Care Explorations. 2021; 3(4): e0389 | | [Pubmed] | [DOI] | | | 40 |
Effect of IV High-Dose Vitamin C on Mortality in Patients With Sepsis |
|
| Ryota Sato, Daisuke Hasegawa, Narut Prasitlumkum, Miki Ueoka, Kazuki Nishida, Kunihiko Takahashi, Michitaka Nasu, Siddharth Dugar | | Critical Care Medicine. 2021; Publish Ah | | [Pubmed] | [DOI] | | | 41 |
Orange You Wishing There Were Definitive Randomized Controlled Trials Already?* |
|
| David N. Hager, Ankita Agarwal, Bram Rochwerg | | Critical Care Medicine. 2021; 49(12): 2154 | | [Pubmed] | [DOI] | | | 42 |
The relationship between vitamin C or thiamine levels and outcomes for severe sepsis patients admitted to the ICU |
|
| Nandan Prasad,Anne V. Grossestreuer,Nuala J. Meyer,Sarah M. Perman,Mark E. Mikkelsen,Judd Hollander,David F. Gaieski | | Scientific Reports. 2021; 11(1) | | [Pubmed] | [DOI] | | | 43 |
Novel insights into peptide amidation and amidating activity in the human circulation |
|
| Paul Kaufmann,Andreas Bergmann,Olle Melander | | Scientific Reports. 2021; 11(1) | | [Pubmed] | [DOI] | | | 44 |
Steroid, ascorbic acid, and thiamine in adults with sepsis and septic shock: a systematic review and component network meta-analysis |
|
| Ka Man Fong,Shek Yin Au,George Wing Yiu Ng | | Scientific Reports. 2021; 11(1) | | [Pubmed] | [DOI] | | | 45 |
Ascorbic acid as an adjunctive therapy in critically ill patients with COVID-19: a propensity score matched study |
|
| Khalid Al Sulaiman,Ohoud Aljuhani,Khalid Bin Saleh,Hisham A. Badreldin,Abdullah Al Harthi,Mohammed Alenazi,Aisha Alharbi,Rahmah Algarni,Shmeylan Al Harbi,Abdullah M. Alhammad,Ramesh Vishwakarma,Sarah Aldekhyl | | Scientific Reports. 2021; 11(1) | | [Pubmed] | [DOI] | | | 46 |
Analysis of the Effect of Vitamin C at IC50 on RAW264.7 and K562 Cells Based on 1H NMR Metabonomics |
|
| Hui Li,Yang Lu,Yue Geng | | ACS Food Science & Technology. 2021; | | [Pubmed] | [DOI] | | | 47 |
Vitamin therapy in sepsis |
|
| Eric L. Wald,Colleen M. Badke,Lauren K. Hintz,Michael Spewak,L. Nelson Sanchez-Pinto | | Pediatric Research. 2021; | | [Pubmed] | [DOI] | | | 48 |
Vitamin C – neue Therapiemöglichkeit bei Sepsis? |
|
| Stefan Müller,Thomas Wiesmann,Hinnerk Wulf,Christian Arndt | | AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie. 2021; 56(05): 374 | | [Pubmed] | [DOI] | | | 49 |
Any Role of High-Dose Vitamin C for Septic Shock in 2021? |
|
| Ankita Agarwal,David N. Hager,Jonathan E. Sevransky | | Seminars in Respiratory and Critical Care Medicine. 2021; 42(05): 672 | | [Pubmed] | [DOI] | | | 50 |
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020) |
|
| Moritoki Egi, Hiroshi Ogura, Tomoaki Yatabe, Kazuaki Atagi, Shigeaki Inoue, Toshiaki Iba, Yasuyuki Kakihana, Tatsuya Kawasaki, Shigeki Kushimoto, Yasuhiro Kuroda, Joji Kotani, Nobuaki Shime, Takumi Taniguchi, Ryosuke Tsuruta, Kent Doi, Matsuyuki Doi, Taka-aki Nakada, Masaki Nakane, Seitaro Fujishima, Naoto Hosokawa, Yoshiki Masuda, Asako Matsushima, Naoyuki Matsuda, Kazuma Yamakawa, Yoshitaka Hara, Masaaki Sakuraya, Shinichiro Ohshimo, Yoshitaka Aoki, Mai Inada, Yutaka Umemura, Yusuke Kawai, Yutaka Kondo, Hiroki Saito, Shunsuke Taito, Chikashi Takeda, Takero Terayama, Hideo Tohira, Hideki Hashimoto, Kei Hayashida, Toru Hifumi, Tomoya Hirose, Tatsuma Fukuda, Tomoko Fujii, Shinya Miura, Hideto Yasuda, Toshikazu Abe, Kohkichi Andoh, Yuki Iida, Tadashi Ishihara, Kentaro Ide, Kenta Ito, Yusuke Ito, Yu Inata, Akemi Utsunomiya, Takeshi Unoki, Koji Endo, Akira Ouchi, Masayuki Ozaki, Satoshi Ono, Morihiro Katsura, Atsushi Kawaguchi, Yusuke Kawamura, Daisuke Kudo, Kenji Kubo, Kiyoyasu Kurahashi, | | Acute Medicine & Surgery. 2021; 8(1) | | [Pubmed] | [DOI] | | | 51 |
Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis |
|
| Tomoko Fujii, Georgia Salanti, Alessandro Belletti, Rinaldo Bellomo, Anitra Carr, Toshi A. Furukawa, Nora Luethi, Yan Luo, Alessandro Putzu, Chiara Sartini, Yasushi Tsujimoto, Andrew A. Udy, Fumitaka Yanase, Paul J. Young | | Intensive Care Medicine. 2021; | | [Pubmed] | [DOI] | | | 52 |
Vitamina C, tiamina e hidrocortisona en choque séptico (protocolo VITHA): estudio de cohortes |
|
| Claudia Patricia Cardona Campo,José Fernando Gómez González,Germán Alberto Moreno Gómez,Andrés Mauricio García Cuevas,Carlos Mario Sánchez Cadavid,Edgardo Quiñones Quiñones | | Acta Colombiana de Cuidado Intensivo. 2021; | | [Pubmed] | [DOI] | | | 53 |
The effect of vitamin C on pulmonary oedema in patients with severe preeclampsia: A single-centre, randomised, placebo-controlled, double-blind trial |
|
| Monika Korenc,Laurent Zieleskiewicz,Tatjana Stopar Pintaric,Iva Blajic,Jana Ambrozic,Miha Lucovnik | | Anaesthesia Critical Care & Pain Medicine. 2021; 40(1): 100800 | | [Pubmed] | [DOI] | | | 54 |
A pilot study on the melatonin treatment in patients with early septic shock: results of a single-center randomized controlled trial |
|
| Abbas Taher,Farnaz Shokoohmand,Elham Abdoli,Younes Mohammadi,Maryam Mehrpooya | | Irish Journal of Medical Science (1971 -). 2021; | | [Pubmed] | [DOI] | | | 55 |
Rapid screening of critically ill patients for low plasma vitamin C concentrations using a point-of-care oxidation–reduction potential measurement |
|
| Sander Rozemeijer,Bob Smit,Paul W. G. Elbers,Armand R. J. Girbes,Heleen M. Oudemans-van Straaten,Angelique M. E. de Man | | Intensive Care Medicine Experimental. 2021; 9(1) | | [Pubmed] | [DOI] | | | 56 |
Mortality in septic patients treated with vitamin C: a systematic meta-analysis |
|
| Sean S. Scholz,Rainer Borgstedt,Nicole Ebeling,Leoni C. Menzel,Gerrit Jansen,Sebastian Rehberg | | Critical Care. 2021; 25(1) | | [Pubmed] | [DOI] | | | 57 |
Measuring vitamin C in critically ill patients: clinical importance and practical difficulties—Is it time for a surrogate marker? |
|
| Sander Rozemeijer,Frans A. L. van der Horst,Angélique M. E. de Man | | Critical Care. 2021; 25(1) | | [Pubmed] | [DOI] | | | 58 |
Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial |
|
| Sander Rozemeijer,Harm-Jan de Grooth,Paul W. G. Elbers,Armand R. J. Girbes,Corstiaan A. den Uil,Eric A. Dubois,Evert-Jan Wils,Thijs C. D. Rettig,Arthur R. H. van Zanten,Roel Vink,Bas van den Bogaard,Rob J. Bosman,Heleen M. Oudemans-van Straaten,Angélique M. E. de Man | | Trials. 2021; 22(1) | | [Pubmed] | [DOI] | | | 59 |
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020) |
|
| Moritoki Egi, Hiroshi Ogura, Tomoaki Yatabe, Kazuaki Atagi, Shigeaki Inoue, Toshiaki Iba, Yasuyuki Kakihana, Tatsuya Kawasaki, Shigeki Kushimoto, Yasuhiro Kuroda, Joji Kotani, Nobuaki Shime, Takumi Taniguchi, Ryosuke Tsuruta, Kent Doi, Matsuyuki Doi, Taka-aki Nakada, Masaki Nakane, Seitaro Fujishima, Naoto Hosokawa, Yoshiki Masuda, Asako Matsushima, Naoyuki Matsuda, Kazuma Yamakawa, Yoshitaka Hara, Masaaki Sakuraya, Shinichiro Ohshimo, Yoshitaka Aoki, Mai Inada, Yutaka Umemura, Yusuke Kawai, Yutaka Kondo, Hiroki Saito, Shunsuke Taito, Chikashi Takeda, Takero Terayama, Hideo Tohira, Hideki Hashimoto, Kei Hayashida, Toru Hifumi, Tomoya Hirose, Tatsuma Fukuda, Tomoko Fujii, Shinya Miura, Hideto Yasuda, Toshikazu Abe, Kohkichi Andoh, Yuki Iida, Tadashi Ishihara, Kentaro Ide, Kenta Ito, Yusuke Ito, Yu Inata, Akemi Utsunomiya, Takeshi Unoki, Koji Endo, Akira Ouchi, Masayuki Ozaki, Satoshi Ono, Morihiro Katsura, Atsushi Kawaguchi, Yusuke Kawamura, Daisuke Kudo, Kenji Kubo, Kiyoyasu Kurahashi, | | Journal of Intensive Care. 2021; 9(1) | | [Pubmed] | [DOI] | | | 60 |
Effect of Vitamin C on mortality of critically ill patients with severe pneumonia in intensive care unit: a preliminary study |
|
| Ata Mahmoodpoor,Kamran Shadvar,Sarvin Sanaie,Mir Reza Hadipoor,Mohammad Ata Pourmoghaddam,Seied Hadi Saghaleini | | BMC Infectious Diseases. 2021; 21(1) | | [Pubmed] | [DOI] | | | 61 |
Effect of vitamin C in critically ill patients with sepsis and septic shock: A meta-analysis |
|
| Fang Feng, Huyong Yang, Weiwei Yang, Min Li, Xueni Chang, Yu Chen | | Science Progress. 2021; 104(1): 0036850421 | | [Pubmed] | [DOI] | | | 62 |
ABC’s of Vitamin Supplementation in Critical Illness |
|
| Melissa Chudow, Beatrice Adams | | Journal of Pharmacy Practice. 2021; 34(6): 934 | | [Pubmed] | [DOI] | | | 63 |
Combined hydrocortisone, ascorbic acid, and thiamine therapy for septic shock with complicated intraabdominal infection: before and after cohort study |
|
| Yong Oh Kim,Kee Sang Yoo,Kyoung Won Yoon,Hyo Jung Park,Chi-Min Park | | Annals of Surgical Treatment and Research. 2021; 100(6): 356 | | [Pubmed] | [DOI] | | | 64 |
Ex Vivo Evaluation of the Sepsis Triple Therapy High-Dose Vitamin C in Combination with Vitamin B1 and Hydrocortisone in a Human Peripheral Blood Mononuclear Cells (PBMCs) Model |
|
| Annie Lauer,Markus Burkard,Heike Niessner,Christian Leischner,Olga Renner,Claudia Vollbracht,Holger Michels,Christian Busch,Tobias Sinnberg,Sascha Venturelli | | Nutrients. 2021; 13(7): 2366 | | [Pubmed] | [DOI] | | | 65 |
Vitamin C in Critically Ill Patients: An Updated Systematic Review and Meta-Analysis |
|
| Dhan Bahadur Shrestha,Pravash Budhathoki,Yub Raj Sedhai,Sujit Kumar Mandal,Shreeja Shikhrakar,Saurab Karki,Ram Kaji Baniya,Markos G. Kashiouris,Xian Qiao,Alpha A. Fowler | | Nutrients. 2021; 13(10): 3564 | | [Pubmed] | [DOI] | | | 66 |
Micronutrients in Sepsis and COVID-19: A Narrative Review on What We Have Learned and What We Want to Know in Future Trials |
|
| Matteo Rossetti,Gennaro Martucci,Christina Starchl,Karin Amrein | | Medicina. 2021; 57(5): 419 | | [Pubmed] | [DOI] | | | 67 |
SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress |
|
| Ryan Chang,Abrar Mamun,Abishai Dominic,Nhat-Tu Le | | Frontiers in Physiology. 2021; 11 | | [Pubmed] | [DOI] | | | 68 |
Targeting Oxidative Stress in Septic Acute Kidney Injury: From Theory to Practice |
|
| Connie P. C. Ow,Anton Trask-Marino,Ashenafi H. Betrie,Roger G. Evans,Clive N. May,Yugeesh R. Lankadeva | | Journal of Clinical Medicine. 2021; 10(17): 3798 | | [Pubmed] | [DOI] | | | 69 |
Vitamin C and COVID-19 |
|
| Harri Hemilä,Angelique M. E. de Man | | Frontiers in Medicine. 2021; 7 | | [Pubmed] | [DOI] | | | 70 |
Reanalysis of the Effect of Vitamin C on Mortality in the CITRIS-ALI Trial: Important Findings Dismissed in the Trial Report |
|
| Harri Hemilä,Elizabeth Chalker | | Frontiers in Medicine. 2020; 7 | | [Pubmed] | [DOI] | | | 71 |
General Adaptation in Critical Illness: Glucocorticoid Receptor-alpha Master Regulator of Homeostatic Corrections |
|
| Gianfranco Umberto Meduri,George P. Chrousos | | Frontiers in Endocrinology. 2020; 11 | | [Pubmed] | [DOI] | | | 72 |
Glucocorticoids in Sepsis: To Be or Not to Be |
|
| Jolien Vandewalle,Claude Libert | | Frontiers in Immunology. 2020; 11 | | [Pubmed] | [DOI] | | | 73 |
The Long History of Vitamin C: From Prevention of the Common Cold to Potential Aid in the Treatment of COVID-19 |
|
| Giuseppe Cerullo,Massimo Negro,Mauro Parimbelli,Michela Pecoraro,Simone Perna,Giorgio Liguori,Mariangela Rondanelli,Hellas Cena,Giuseppe D’Antona | | Frontiers in Immunology. 2020; 11 | | [Pubmed] | [DOI] | | | 74 |
Impact of Vitamin C and Thiamine Administration on Delirium-Free Days in Patients with Septic Shock |
|
| Jong Eun Park,Tae Gun Shin,Ik Joon Jo,Kyeongman Jeon,Gee Young Suh,Minsu Park,Hojeong Won,Chi Ryang Chung,Sung Yeon Hwang | | Journal of Clinical Medicine. 2020; 9(1): 193 | | [Pubmed] | [DOI] | | | 75 |
The Emerging Role of Vitamin C as a Treatment for Sepsis |
|
| Markos G. Kashiouris,Michael L’Heureux,Casey A. Cable,Bernard J. Fisher,Stefan W. Leichtle,Alpha A. Fowler | | Nutrients. 2020; 12(2): 292 | | [Pubmed] | [DOI] | | | 76 |
Vitamin C—An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19 |
|
| Patrick Holford,Anitra C. Carr,Thomas H. Jovic,Stephen R. Ali,Iain S. Whitaker,Paul E. Marik,A. David Smith | | Nutrients. 2020; 12(12): 3760 | | [Pubmed] | [DOI] | | | 77 |
Hydrocortisone, ascorbic acid and thiamine for sepsis: Is the jury out? |
|
| Paul Ellis Marik,Joseph Varon,Salim Surani | | World Journal of Diabetes. 2020; 11(4): 90 | | [Pubmed] | [DOI] | | | 78 |
Role of vitamin C in critically ill patients with COVID-19: is it effective? |
|
| Siddique Mohyud Din Chaudhary,Robert Matthew Wright,Gabriel Patarroyo-Aponte | | Acute and Critical Care. 2020; 35(4): 307 | | [Pubmed] | [DOI] | | | 79 |
Metabolic Resuscitation Using Hydrocortisone, Ascorbic Acid, and Thiamine: Do Individual Components Influence Reversal of Shock Independently? |
|
| Paidi Ramakrishna Reddy,Sangeeta Yelle,Boggu Rajyalakshmi | | Indian Journal of Critical Care Medicine. 2020; 24(8): 649 | | [Pubmed] | [DOI] | | | 80 |
Vasoplegia after cardiopulmonary bypass: A narrative review of pathophysiology and emerging targeted therapies |
|
| Theresa J Barnes, Maxwell A Hockstein, Craig S Jabaley | | SAGE Open Medicine. 2020; 8: 2050312120 | | [Pubmed] | [DOI] | | | 81 |
Effects of thiamine on vasopressor requirements in patients with septic shock: a prospective randomized controlled trial |
|
| Suttasinee Petsakul,Sunthiti Morakul,Viratch Tangsujaritvijit,Parinya Kunawut,Pongsasit Singhatas,Pitsucha Sanguanwit | | BMC Anesthesiology. 2020; 20(1) | | [Pubmed] | [DOI] | | | 82 |
Ascorbic Acid, Thiamine, and Steroids in Septic Shock: Propensity Matched Analysis |
|
| Farid Sadaka,Justin Grady,Nikhil Organti,Bhargavi Donepudi,Matthew Korobey,David Tannehill,Jacklyn O’Brien | | Journal of Intensive Care Medicine. 2020; 35(11): 1302 | | [Pubmed] | [DOI] | | | 83 |
Vitamin C, Thiamine, and Steroids in the Sepsis Conquest: Replete to Defeat |
|
| Erenie Guirguis,Yasmin Grace,Harm Maarsingh,Thi Ca Tran,Elena Tkachuk | | Journal of Pharmacy Practice. 2020; 33(5): 682 | | [Pubmed] | [DOI] | | | 84 |
Hydrocortisone–Ascorbic Acid–Thiamine Use Associated with Lower Mortality in Pediatric Septic Shock |
|
| Eric L. Wald,L. Nelson Sanchez-Pinto,Craig M. Smith,Thomas Moran,Colleen M. Badke,Matthew F. Barhight,Marcelo R. Malakooti | | American Journal of Respiratory and Critical Care Medicine. 2020; 201(7): 863 | | [Pubmed] | [DOI] | | | 85 |
Lessening Organ dysfunction with VITamin C (LOVIT): protocol for a randomized controlled trial |
|
| Marie-Hélène Masse,Julie Ménard,Sheila Sprague,Marie-Claude Battista,Deborah J. Cook,Gordon H. Guyatt,Daren K. Heyland,Salmaan Kanji,Ruxandra Pinto,Andrew G. Day,Dian Cohen,Djillali Annane,Shay McGuinness,Rachael Parke,Anitra Carr,Yaseen Arabi,Bharath Kumar Tirupakuzhi Vijayaraghavan,Frédérick D’Aragon,Élaine Carbonneau,David Maslove,Miranda Hunt,Bram Rochwerg,Tina Millen,Michaël Chassé,Martine Lebrasseur,Patrick Archambault,Estel Deblois,Christine Drouin,François Lellouche,Patricia Lizotte,Irene Watpool,Rebecca Porteous,France Clarke,Nicole Marinoff,Émilie Belley-Côté,Brigitte Bolduc,Scott Walker,John Iazzetta,Neill K. J. Adhikari,François Lamontagne | | Trials. 2020; 21(1) | | [Pubmed] | [DOI] | | | 86 |
Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review |
|
| Patrick M. Honore,Herbert D. Spapen,Paul Marik,Willem Boer,Heleen Oudemans-van Straaten | | Annals of Intensive Care. 2020; 10(1) | | [Pubmed] | [DOI] | | | 87 |
Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis |
|
| Harri Hemilä,Elizabeth Chalker | | Journal of Intensive Care. 2020; 8(1) | | [Pubmed] | [DOI] | | | 88 |
Reversal of Vasodilatory Shock |
|
| Jonathan H. Chow,Ezeldeen Abuelkasem,Susan Sankova,Reney A. Henderson,Michael A. Mazzeffi,Kenichi A. Tanaka | | Anesthesia & Analgesia. 2020; 130(1): 15 | | [Pubmed] | [DOI] | | | 89 |
The Potential Influence of Vitamin A, C, and D and Zinc Supplements on the Severity of COVID-19 Symptoms and Clinical Outcomes: An Updated Review of Literature |
|
| Abeer Salman Alzaben | | Current Research in Nutrition and Food Science Journal. 2020; 8(3): 703 | | [Pubmed] | [DOI] | | | 90 |
Vitamin C measurement in critical illness: challenges, methodologies and quality improvements |
|
| Jake T.B. Collie,Ronda F. Greaves,Oliver A.H. Jones,Glenn Eastwood,Rinaldo Bellomo | | Clinical Chemistry and Laboratory Medicine (CCLM). 2020; 58(4): 460 | | [Pubmed] | [DOI] | | | 91 |
The Effect of the Vitamin Protocol for Treating Sepsis or Septic Shock in Pediatric Intensive Care Unit |
|
| Hyun Jung Ko,Min Jae Jung,Jae Song Kim,Eun Sun Son,Yun Mi Yu | | Korean Journal of Clinical Pharmacy. 2020; 30(3): 161 | | [Pubmed] | [DOI] | | | 92 |
Sepsis-Induced Cardiomyopathy: a Comprehensive Review |
|
| Michael L’Heureux,Michael Sternberg,Lisa Brath,Jeremy Turlington,Markos G. Kashiouris | | Current Cardiology Reports. 2020; 22(5) | | [Pubmed] | [DOI] | | | 93 |
Overview of the possible role of vitamin C in management of COVID-19 |
|
| Anis Abobaker,Aboubaker Alzwi,Alsalheen Hamed A. Alraied | | Pharmacological Reports. 2020; | | [Pubmed] | [DOI] | | | 94 |
Treating sepsis with vitamin C, thiamine, and hydrocortisone: Exploring the quest for the magic elixir |
|
| J. Obi,S.M. Pastores,L.V. Ramanathan,J. Yang,N.A. Halpern | | Journal of Critical Care. 2020; | | [Pubmed] | [DOI] | | | 95 |
Adjunctive therapy with vitamin c and thiamine in patients treated with steroids for refractory septic shock: A propensity matched before-after, case-control study |
|
| Coloretti Irene,Biagioni Emanuela,Venturelli Sophie,Munari Elena,Martina Tosi,Roat Erika,Brugioni Lucio,Gelmini Roberta,Venturelli Claudia,Girardis Massimo | | Journal of Critical Care. 2020; | | [Pubmed] | [DOI] | | | 96 |
The critical care literature 2019 |
|
| Michael E. Winters,Kami Hu,Joseph P. Martinez,Haney Mallemat,William J. Brady | | The American Journal of Emergency Medicine. 2020; | | [Pubmed] | [DOI] | | | 97 |
In Vitro and In Silico Analysis of Ascorbic Acid Towards Lanosterol 14-a-Demethylase Enzyme of Fluconazole-Resistant Candida albicans |
|
| Arumugam Ganeshkumar,Suvaiyarasan Suvaithenamudhan,Rajendran Rajaram | | Current Microbiology. 2020; | | [Pubmed] | [DOI] | | | 98 |
Sepsis-Induced Myocardial Dysfunction (SIMD): the Pathophysiological Mechanisms and Therapeutic Strategies Targeting Mitochondria |
|
| Yao Lin,Yinchuan Xu,Zhaocai Zhang | | Inflammation. 2020; | | [Pubmed] | [DOI] | | | 99 |
Lack of Benefit of High-Dose Vitamin C, Thiamine, and Hydrocortisone Combination for Patients With Sepsis |
|
| Andre C. Kalil | | JAMA. 2020; | | [Pubmed] | [DOI] | | | 100 |
A Possible Application of High Dose Vitamin C in the Prevention and Therapy for Coronavirus Infections |
|
| Ba X. Hoang,D. Graeme Shaw,William Fang,Bo Han | | Journal of Global Antimicrobial Resistance. 2020; | | [Pubmed] | [DOI] | | | 101 |
Vitamin C levels amongst initial survivors of out of hospital cardiac arrest |
|
| Ryan Gardner,Xiaowen Liu,Yanbo Wang,Andrew Cole,Stanley Heydrick,Michael W. Donnino,Ari Moskowitz | | Resuscitation. 2020; 156: 190 | | [Pubmed] | [DOI] | | | 102 |
Vitamin C in health and disease: A companion animal focus |
|
| D.S. Gordon,A.J. Rudinsky,J. Guillaumin,V.J. Parker,K.J. Creighton | | Topics in Companion Animal Medicine. 2020; : 100432 | | [Pubmed] | [DOI] | | | 103 |
Nouveautés dans les traitements du choc septique et état de la recherche |
|
| Nicolas Herzog, Fanny Jouquand, Philippe Aries, Christophe Giacardi, Médéric Rouault | | La Revue de l'Infirmière. 2020; 69(260-261): 19 | | [Pubmed] | [DOI] | | | 104 |
Surgical Infection Society Research Priorities: A Narrative Review of Fourteen Years of Progress |
|
| Tina S. Mele,Haytham M.A. Kaafarani,Christopher A. Guidry,Michele M. Loor,David Machado-Aranda,April E. Mendoza,Gareth Morris-Stiff,Rishi Rattan,Sebastian D. Schubl,Philip S. Barie | | Surgical Infections. 2020; | | [Pubmed] | [DOI] | | | 105 |
Safety, Pharmacodynamics, and Efficacy of High- Versus Low-Dose Ascorbic Acid in Severely Burned Adults |
|
| Sarah Sophie Nagel,Christian Andreas Radu,Thomas Kremer,David Meess,Johannes Horter,Benjamin Ziegler,Christoph Hirche,Volker Juergen Schmidt,Ulrich Kneser,Gabriel Hundeshagen | | Journal of Burn Care & Research. 2020; | | [Pubmed] | [DOI] | | | 106 |
Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children |
|
| Scott L. Weiss,Mark J. Peters,Waleed Alhazzani,Michael S. D. Agus,Heidi R. Flori,David P. Inwald,Simon Nadel,Luregn J. Schlapbach,Robert C. Tasker,Andrew C. Argent,Joe Brierley,Joseph Carcillo,Enitan D. Carrol,Christopher L. Carroll,Ira M. Cheifetz,Karen Choong,Jeffry J. Cies,Andrea T. Cruz,Daniele De Luca,Akash Deep,Saul N. Faust,Claudio Flauzino De Oliveira,Mark W. Hall,Paul Ishimine,Etienne Javouhey,Koen F. M. Joosten,Poonam Joshi,Oliver Karam,Martin C. J. Kneyber,Joris Lemson,Graeme MacLaren,Nilesh M. Mehta,Morten Hylander Møller,Christopher J. L. Newth,Trung C. Nguyen,Akira Nishisaki,Mark E. Nunnally,Margaret M. Parker,Raina M. Paul,Adrienne G. Randolph,Suchitra Ranjit,Lewis H. Romer,Halden F. Scott,Lyvonne N. Tume,Judy T. Verger,Eric A. Williams,Joshua Wolf,Hector R. Wong,Jerry J. Zimmerman,Niranjan Kissoon,Pierre Tissieres | | Intensive Care Medicine. 2020; 46(S1): 10 | | [Pubmed] | [DOI] | | | 107 |
Harm of IV High-Dose Vitamin C Therapy in Adult Patients |
|
| Fumitaka Yanase, Tomoko Fujii, Thummaporn Naorungroj, Alessandro Belletti, Nora Luethi, Anitra C. Carr, Paul J. Young, Rinaldo Bellomo | | Critical Care Medicine. 2020; Publish Ah | | [Pubmed] | [DOI] | | | 108 |
Vitamin C and thiamine are associated with lower mortality in sepsis |
|
| Saskya Byerly,Joshua P. Parreco,Hahn Soe-Lin,Jonathan J. Parks,Eugenia E. Lee,Ilya Shnaydman,Alejandro Mantero,D. Dante Yeh,Nicholas Namias,Rishi Rattan | | Journal of Trauma and Acute Care Surgery. 2020; 89(1): 111 | | [Pubmed] | [DOI] | | | 109 |
Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children |
|
| Scott L. Weiss,Mark J. Peters,Waleed Alhazzani,Michael S. D. Agus,Heidi R. Flori,David P. Inwald,Simon Nadel,Luregn J. Schlapbach,Robert C. Tasker,Andrew C. Argent,Joe Brierley,Joseph Carcillo,Enitan D. Carrol,Christopher L. Carroll,Ira M. Cheifetz,Karen Choong,Jeffry J. Cies,Andrea T. Cruz,Daniele De Luca,Akash Deep,Saul N. Faust,Claudio Flauzino De Oliveira,Mark W. Hall,Paul Ishimine,Etienne Javouhey,Koen F. M. Joosten,Poonam Joshi,Oliver Karam,Martin C. J. Kneyber,Joris Lemson,Graeme MacLaren,Nilesh M. Mehta,Morten Hylander Møller,Christopher J. L. Newth,Trung C. Nguyen,Akira Nishisaki,Mark E. Nunnally,Margaret M. Parker,Raina M. Paul,Adrienne G. Randolph,Suchitra Ranjit,Lewis H. Romer,Halden F. Scott,Lyvonne N. Tume,Judy T. Verger,Eric A. Williams,Joshua Wolf,Hector R. Wong,Jerry J. Zimmerman,Niranjan Kissoon,Pierre Tissieres | | Pediatric Critical Care Medicine. 2020; 21(2): e52 | | [Pubmed] | [DOI] | | | 110 |
Safety of vitamin C in sepsis |
|
| Niloofar Khoshnam-Rad,Hossein Khalili | | Current Opinion in Critical Care. 2019; 25(4): 329 | | [Pubmed] | [DOI] | | | 111 |
Vitamin C in surgical sepsis |
|
| Tanya Anand,Lauren K. Roller,Gregory J. Jurkovich | | Current Opinion in Critical Care. 2019; 25(6): 712 | | [Pubmed] | [DOI] | | | 112 |
Reduced plasma ascorbic acid levels in recipients of myeloablative conditioning and hematopoietic cell transplantation |
|
| Mahmood Rasheed,Gary Simmons,Bernard Fisher,Kevin Leslie,Jason Reed,Catherine Roberts,Ramesh Natarajan,Alpha Fowler,Amir Toor | | European Journal of Haematology. 2019; | | [Pubmed] | [DOI] | | | 113 |
Sepsis 2019: What Surgeons Need to Know |
|
| Vanessa P. Ho,Haytham Kaafarani,Rishi Rattan,Nicholas Namias,Heather Evans,Tanya L. Zakrison | | Surgical Infections. 2019; | | [Pubmed] | [DOI] | | | 114 |
Sepsis - What's new in 2019? |
|
| Mark E. Nunnally,Arpit Patel | | Current Opinion in Anaesthesiology. 2019; 32(2): 163 | | [Pubmed] | [DOI] | | | 115 |
The Effect of Vitamin C on Clinical Outcome in Critically Ill Patients |
|
| Alessandro Putzu,Anne-Marie Daems,Juan Carlos Lopez-Delgado,Vito Federico Giordano,Giovanni Landoni | | Critical Care Medicine. 2019; 47(6): 774 | | [Pubmed] | [DOI] | | | 116 |
Understanding Vitamin C in Critical Illness |
|
| Michael H. Hooper,David N. Hager | | Critical Care Medicine. 2019; 47(6): 867 | | [Pubmed] | [DOI] | | | 117 |
Reporting of Organ Support Outcomes in Septic Shock Randomized Controlled Trials |
|
| Simon Bourcier,Patrick Hindlet,Bertrand Guidet,Agnès Dechartres | | Critical Care Medicine. 2019; 47(7): 984 | | [Pubmed] | [DOI] | | | 118 |
Lactated Ringer’s Versus 4% Albumin on Lactated Ringer’s in Early Sepsis Therapy in Cancer Patients |
|
| Clarice Hyesuk Lee Park,Juliano Pinheiro de Almeida,Gisele Queiroz de Oliveira,Stéphanie Itala Rizk,Julia Tizue Fukushima,Rosana Ely Nakamura,Matheus Moraes Mourão,Filomena Regina Barbosa Gomes Galas,Edson Abdala,Maristela Pinheiro Freire,Roberto Kalil Filho,Jose Otavio Costa Auler,Pasquale Nardelli,Greg S. Martin,Giovanni Landoni,Ludhmila Abrahao Hajjar | | Critical Care Medicine. 2019; 47(10): e798 | | [Pubmed] | [DOI] | | | 119 |
Challenges in the management of septic shock: a narrative review |
|
| Daniel De Backer,Maurizio Cecconi,Jeffrey Lipman,Flavia Machado,Sheila Nainan Myatra,Marlies Ostermann,Anders Perner,Jean-Louis Teboul,Jean-Louis Vincent,Keith R. Walley | | Intensive Care Medicine. 2019; | | [Pubmed] | [DOI] | | | 120 |
Efficacy of vitamin C in patients with sepsis: A updated meta-analysis |
|
| Xue-biao Wei,Zhong-hua Wang,Xiao-long Liao,Wei-xin Guo,Jian-Yi Wen,Tie-he Qin,Shou-hong Wang | | European Journal of Pharmacology. 2019; : 172889 | | [Pubmed] | [DOI] | | | 121 |
Different doses of vitamin C supplementation enhances the Th1 immune response to early Plasmodium yoelii 17XL infection in BALB/c mice |
|
| Xiaosong Qin,Jianhua Liu,Yunting Du,Ying Li,Li Zheng,Guang Chen,Yaming Cao | | International Immunopharmacology. 2019; 70: 387 | | [Pubmed] | [DOI] | | | 122 |
Pharmacologic Agents for the Treatment of Vasodilatory Shock |
|
| Hans Knotzer,Bernhard Poidinger,Axel Kleinsasser | | Current Pharmaceutical Design. 2019; 25(19): 2133 | | [Pubmed] | [DOI] | | | 123 |
Revisiting the Role of Vitamin C in Sepsis. Is it a Forlorn Hope or is there Still Dearth of data? |
|
| Salim Surani,Munish Sharma | | The Open Respiratory Medicine Journal. 2019; 13(1): 55 | | [Pubmed] | [DOI] | | | 124 |
Effects of different ascorbic acid doses on the mortality of critically ill patients: a meta-analysis |
|
| Ying Wang,Huan Lin,Bing-wen Lin,Jian-dong Lin | | Annals of Intensive Care. 2019; 9(1) | | [Pubmed] | [DOI] | | | 125 |
Adjunctive Therapies in the Management of Septic Shock |
|
| Raj Parikh,Samuel H. Belok,Lakshmana Swamy,Christine C. Reardon | | American Journal of Respiratory and Critical Care Medicine. 2019; 200(3): 381 | | [Pubmed] | [DOI] | | | 126 |
The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial |
|
| David N. Hager,Michael H. Hooper,Gordon R. Bernard,Laurence W. Busse,E. Wesley Ely,Alpha A. Fowler,David F. Gaieski,Alex Hall,Jeremiah S. Hinson,James C. Jackson,Gabor D. Kelen,Mark Levine,Christopher J. Lindsell,Richard E. Malone,Anna McGlothlin,Richard E. Rothman,Kert Viele,David W. Wright,Jonathan E. Sevransky,Greg S. Martin | | Trials. 2019; 20(1) | | [Pubmed] | [DOI] | | | 127 |
Combination therapy of vitamin C and thiamine for septic shock in a multicentre, double-blind, randomized, controlled study (ATESS): study protocol for a randomized controlled trial |
|
| Sung Yeon Hwang,Jong Eun Park,Ik Joon Jo,Seonwoo Kim,Sung Phil Chung,Taeyoung Kong,Jonghwan Shin,Hui Jai Lee,Kyoung Min You,You Hwan Jo,Doyun Kim,Gil Joon Suh,Taegyun Kim,Won Young Kim,Youn-Jung Kim,Seung Mok Ryoo,Sung-Hyuk Choi,Tae Gun Shin | | Trials. 2019; 20(1) | | [Pubmed] | [DOI] | | | 128 |
Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis |
|
| Harri Hemilä,Elizabeth Chalker | | Nutrients. 2019; 11(4): 708 | | [Pubmed] | [DOI] | | | 129 |
Perioperative Vitamin C and E levels in Cardiac Surgery Patients and Their Clinical Significance |
|
| Aileen Hill,Christina Borgs,Christina Fitzner,Christian Stoppe | | Nutrients. 2019; 11(9): 2157 | | [Pubmed] | [DOI] | | | 130 |
Early Vitamin C and Thiamine Administration to Patients with Septic Shock in Emergency Departments: Propensity Score-Based Analysis of a Before-and-After Cohort Study |
|
| Tae Gun Shin,Youn-Jung Kim,Seung Mok Ryoo,Sung Yeon Hwang,Ik Joon Jo,Sung Phil Chung,Sung-Hyuk Choi,Gil Joon Suh,Won Young Kim | | Journal of Clinical Medicine. 2019; 8(1): 102 | | [Pubmed] | [DOI] | | | 131 |
The Use of Intravenous Vitamin C as a Supportive Therapy for a Patient with Glioblastoma Multiforme |
|
| Nicola Baillie,Anitra Carr,Selene Peng | | Antioxidants. 2018; 7(9): 115 | | [Pubmed] | [DOI] | | | 132 |
Vitamin C and Helicobacter pylori Infection: Current Knowledge and Future Prospects |
|
| Haixin Mei,Hongbin Tu | | Frontiers in Physiology. 2018; 9 | | [Pubmed] | [DOI] | | | 133 |
Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients—Review and Pragmatic Approach |
|
| Aileen Hill,Sebastian Wendt,Carina Benstoem,Christina Neubauer,Patrick Meybohm,Pascal Langlois,Neill Adhikari,Daren Heyland,Christian Stoppe | | Nutrients. 2018; 10(8): 974 | | [Pubmed] | [DOI] | | | 134 |
Recognition and Management of Sepsis in the Obstetric Patient |
|
| Sheryl E. Parfitt,Sandra L. Hering | | AACN Advanced Critical Care. 2018; 29(3): 303 | | [Pubmed] | [DOI] | | | 135 |
Recent advances in nanomedicine for sepsis treatment |
|
| Simseok A Yuk,Diego A Sanchez-Rodriguez,Michael D Tsifansky,Yoon Yeo | | Therapeutic Delivery. 2018; 9(6): 435 | | [Pubmed] | [DOI] | | | 136 |
Making sense of early high-dose intravenous vitamin C in ischemia/reperfusion injury |
|
| Angelique M. E. Spoelstra-de Man,Paul W. G. Elbers,Heleen M. Oudemans-van Straaten | | Critical Care. 2018; 22(1) | | [Pubmed] | [DOI] | | | 137 |
Refractory septic shock: our pragmatic approach |
|
| Prashanth Nandhabalan,Nicholas Ioannou,Christopher Meadows,Duncan Wyncoll | | Critical Care. 2018; 22(1) | | [Pubmed] | [DOI] | | | 138 |
Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis |
|
| Jing Li | | Critical Care. 2018; 22(1) | | [Pubmed] | [DOI] | | | 139 |
Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation |
|
| Ari Moskowitz,Lars W. Andersen,David T. Huang,Katherine M. Berg,Anne V. Grossestreuer,Paul E. Marik,Robert L. Sherwin,Peter C. Hou,Lance B. Becker,Michael N. Cocchi,Pratik Doshi,Jonathan Gong,Ayan Sen,Michael W. Donnino | | Critical Care. 2018; 22(1) | | [Pubmed] | [DOI] | | | 140 |
Vitamin C: The next step in sepsis management? |
|
| J. Teng,A. Pourmand,M. Mazer-Amirshahi | | Journal of Critical Care. 2018; 43: 230 | | [Pubmed] | [DOI] | | | 141 |
Combined vitamin C, hydrocortisone, and thiamine therapy for patients with severe pneumonia who were admitted to the intensive care unit: Propensity score-based analysis of a before-after cohort study |
|
| Won-Young Kim,Eun-Jung Jo,Jung Seop Eom,Jeongha Mok,Mi-Hyun Kim,Ki Uk Kim,Hye-Kyung Park,Min Ki Lee,Kwangha Lee | | Journal of Critical Care. 2018; 47: 211 | | [Pubmed] | [DOI] | | | 142 |
Vitamin C Supplementation in the Critically Ill: A Systematic Review and Meta-Analysis |
|
| Pascal L. Langlois,William Manzanares,Neill K. J. Adhikari,François Lamontagne,Christian Stoppe,Aileen Hill,Daren K. Heyland | | Journal of Parenteral and Enteral Nutrition. 2018; | | [Pubmed] | [DOI] | | | 143 |
Vitamin therapy in critically ill patients: focus on thiamine, vitamin C, and vitamin D |
|
| Karin Amrein,Heleen M. Oudemans-van Straaten,Mette M. Berger | | Intensive Care Medicine. 2018; | | [Pubmed] | [DOI] | | | 144 |
A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D |
|
| Justin B. Belsky,Charles R. Wira,Vinitha Jacob,John E. Sather,Patty J. Lee | | Nutrition Research Reviews. 2018; : 1 | | [Pubmed] | [DOI] | | | 145 |
Vitamin C for the critically ills: is the evidence strong enough? |
|
| Pascal L. Langlois,François Lamontage | | Nutrition. 2018; | | [Pubmed] | [DOI] | | | 146 |
Vitamin C for the treatment of sepsis: The scientific rationale |
|
| Paul E. Marik | | Pharmacology & Therapeutics. 2018; | | [Pubmed] | [DOI] | | | 147 |
A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Reducing Mortality |
|
| Chiara Sartini,Vladimir Lomivorotov,Marina Pieri,Juan Carlos Lopez Delgado,Martina Baiardo Redaelli,Ludhmila Hajjar,Antonio Pisano,Valery Likhvantsev,Evgeny Fominskiy,Nikola Bradic,Luca Cabrini,Maxim Novikov,Daniele Avancini,Hynek Riha,Rosalba Lembo,Gordana Gazivoda,Gianluca Paternoster,Chengbin Wang,Simona Tamà,Gabriele Alvaro,Chew Yin Wang,Agostino Roasio,Laura Ruggeri,Chow-Yen Yong,Daniela Pasero,Luca Severi,Laura Pasin,Giuseppe Mancino,Paolo Mura,Mario Musu,Savino Spadaro,Massimiliano Conte,Rosetta Lobreglio,Simona Silvetti,Carmine Domenico Votta,Alessandro Belletti,Diana Di Fraja,Francesco Corradi,Claudia Brusasco,Emanuela Saporito,Alessandro DæAmico,Salvatore Sardo,Alessandro Ortalda,Claudio Riefolo,Monaco Fabrizio,Alberto Zangrillo,Rinaldo Bellomo,Giovanni Landoni | | Journal of Cardiothoracic and Vascular Anesthesia. 2018; | | [Pubmed] | [DOI] | | | 148 |
Metabolic resuscitation strategies to prevent organ dysfunction in sepsis |
|
| Vera Reitsema,Bastiaan Star,Vincent de Jager,Matijs van Meurs,Robert H Henning,Hjalmar Bouma | | Antioxidants & Redox Signaling. 2018; | | [Pubmed] | [DOI] | | | 149 |
Bet 2: Does intravenous vitamin C improve mortality in patients with severe sepsis? |
|
| Mohammed Sheikh,Daniel Horner | | Emergency Medicine Journal. 2018; 35(4): 272 | | [Pubmed] | [DOI] | | | 150 |
Involvement of Aromatic Metabolites in the Pathogenesis of Septic Shock |
|
| Natalia V. Beloborodova,Yulia N. Sarshor,Aleksandra Yu. Bedova,Ekaterina A. Chernevskaya,Alisa K. Pautova | | SHOCK. 2018; 50(3): 273 | | [Pubmed] | [DOI] | | | 151 |
Vitamin C in burns, sepsis, and trauma |
|
| Tanya Anand,Ruby Skinner | | Journal of Trauma and Acute Care Surgery. 2018; 85(4): 782 | | [Pubmed] | [DOI] | | | 152 |
Vitamin C |
|
| Angélique M.E. Spoelstra-de Man,Paul W.G. Elbers,Heleen M. Oudemans-Van Straaten | | Current Opinion in Critical Care. 2018; : 1 | | [Pubmed] | [DOI] | | | 153 |
Vitamin C in the critically ill - indications and controversies |
|
| Christoph S Nabzdyk,Edward A Bittner | | World Journal of Critical Care Medicine. 2018; 7(5): 52 | | [Pubmed] | [DOI] | | | 154 |
Vitamin C in sepsis |
|
| Sven-Olaf Kuhn,Konrad Meissner,Lena M. Mayes,Karsten Bartels | | Current Opinion in Anaesthesiology. 2017; : 1 | | [Pubmed] | [DOI] | |
|
 |
|
|
|
Search Pubmed for
