Journal of Research in Pharmacy Practice

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 1  |  Issue : 1  |  Page : 25--29

Resuscitation of preterm newborns with low concentration oxygen versus high concentration oxygen


Amir Mohammad Armanian, Zohreh Badiee 
 Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Amir Mohammad Armanian
Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan
Iran

Objective: It is well known that a brief exposure to 100% oxygen for only a few minutes could be toxic for a preterm infant. The effectiveness of neonatal resuscitation was compared with low concentration oxygen (30%) and high concentration oxygen (HOG) (100%). Methods: Thirty-two preterm neonates were born in Isfahan Shahid Beheshti hospital with gestational age of 29-34 weeks who required resuscitation were randomized into two groups. The resuscitation was begun with 30% O 2 in low concentration oxygen group (LOG). The infants were examined every 60-90 seconds and if their HR was less than 100, 10% was added to the previous FIO 2 (fraction of inspired oxygen) until the HR increased to 100 and SO 2 (saturation of oxygen) increased to 85%. In HOG resuscitation begun with 100% O 2 and every 60-90 seconds, FIO 2 was decreased 10 - 15% until the HR reached to 100 and SO 2 reached to 85%. Findings: The FIO 2 in LOG was increased stepwise to 45% and in HOG was reduced to 42.1% to reach stable oxygen saturation more than 85% at the fifth minute in both groups. At the first and third minutes after birth and there was no significant differences between groups in heart rate and after 1,2,4 and 5 minutes after the birth there was also no significant differences in SO 2 between groups, regardless of the initial FIO 2 . Conclusion: We can safely initiate resuscitation of preterm infants with a low FIO 2 (approximately 30%) oxygen and then oxygen should be adjusted with the neonates needs.


How to cite this article:
Armanian AM, Badiee Z. Resuscitation of preterm newborns with low concentration oxygen versus high concentration oxygen.J Res Pharm Pract 2012;1:25-29


How to cite this URL:
Armanian AM, Badiee Z. Resuscitation of preterm newborns with low concentration oxygen versus high concentration oxygen. J Res Pharm Pract [serial online] 2012 [cited 2021 Jul 24 ];1:25-29
Available from: https://www.jrpp.net/article.asp?issn=2319-9644;year=2012;volume=1;issue=1;spage=25;epage=29;aulast=Armanian;type=0